维生素K_(1)有关物质的合成

Synthesis of the Related Substances of Vitamin K_(1)

合成了维生素K1的4种可能有关物质,分别是2-[(7R,11R)-2,3-二羟基-3,7,11,15-四甲基十六烷基]-3-甲基萘-1,4-二酮(有关物质A)、1α-甲基-7α-[(7R,11R,E)-3,7,11,15-四甲基十六烷基-2-烯基]-1α,7α-四氢萘并[2,3-b]环氧乙烷-2,7-二酮(有关物质B)、2-[(7R,11R,E)-3-羟基-3,7,11,15-四甲基十六烷基-1-烯基]-3-甲基萘-1,4-二酮(有关物质C)、2,5-二甲基-2-[(4R,8R)-4,8,12-三甲基十三烷基]-2H-苯并[h]色烯-6-酚(有关物质D)。这些化合物均经^(1)H NMR和MS进行了结构确证,为控制原料药维生素K1的质量提供一定的参考。

Four potential related substances were synthesized,namely 2-[(7R,11R)-2,3-dihydroxy-3,7,11,15-tetramethylhexadecyl]-3-methylnaphthalene-1,4-dione(related substance A),1α-methyl-7α-[(7R,11R,E)-3,7,11,15-tetramethylhexadec-2-en-1-yl]-1α,7α-dihydronaphtho[2,3-b]oxirene-2,7-dione(related substance B),2-[(7R,11R,E)-3-hydroxy-3,7,11,15-tetramethylhexadec-1-en-1-yl]-3-methylnaphthalene-1,4-dione(related substance C)and 2,5-dimethyl2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-benzo[h]chromen-6-ol(related substance D).Their structures were confirmed by ^(1)H NMR and MS,which provided a reference for the quality control of vitamin K1.