不同类型程序性细胞死亡在牙周炎中的研究进展

Different types of programmed cell death in periodontitis

牙菌斑是牙周炎的始动因子,而宿主免疫细胞的招募和多种炎症介质的产生导致了牙周组织损伤与破坏。程序性细胞死亡包括细胞凋亡、细胞坏死性凋亡、细胞自噬、细胞焦亡、细胞铁死亡、细胞铜死亡等,其在牙周炎发生发展过程中作用也不尽相同。该文总结了不同类型程序性细胞死亡在牙周炎中的作用特点和研究进展,以期为牙周炎的发病机制提供新的研究思路,并且为牙周炎的精准治疗提供更多参考。

Periodontitis is a chronic inflammatory and destructive disease in which plaque acts as an initiator.Recruitment of host im⁃mune cells and production of multiple inflammatory mediators leads to periodontal tissue damage.Programmed cell death(PCD)is a self⁃destructive process that is actively initiated by cells under specific conditions and can be mainly categorized into apoptosis,necrop⁃tosis,autophagy,pyroptosis,ferroptosis,cuproptosis,etc.Different types of programmed cell death have their own distinctive roles in periodontitis.In this review,we summarizes the characteristics of different types of PCD and their role in the progression of periodonti⁃tis,in order to provide new research ideas on the pathogenic mechanism of periodontitis and more references for the precise treatment of periodontitis.