基于“虚气留滞”理论探讨线粒体功能障碍对心肌缺血再灌注损伤的影响

Impact of mitochondrial dysfunction on myocardial ischemia-reperfusion injury based on the theory of“deficiency qi stagnation”

本文基于“虚气留滞”理论探讨心肌缺血再灌注损伤(MIRI)的病机理论内涵及中医药治疗方法。“虚气”指脏腑精气亏虚,气血阴阳失和,“留滞”指疾病过程中所涉及的各种病理产物的蓄积。“虚气”是导致MIRI的病理基础,为发病之本;“留滞”是导致MIRI的病理关键,为病机之要;两者互相兼夹,互为因果,最终形成“虚”“滞”夹杂,以“虚”为本,以“滞”为标,“虚”“滞”相伴的病理状态。因此,本文基于“虚气留滞”中医基础理论,与现代医学机制中的线粒体功能障碍相结合,探讨二者在MIRI中的相关性,全面诠释“虚气留滞”病机的科学内涵,以期为MIRI的防治提供新思路及中医理论依据。

This article explores the pathogenesis theory and traditional Chinese medicine treatment methods of myocardial ischemia reperfusion injury(MIRI)based on the theory of“deficiency qi stagnation”.“Deficiency Qi”refers to the deficiency of essence and qi in the organs,resulting in disharmony of qi,blood,yin,and yang.“stagnation”refers to the accumulation of various pathological products involved in the disease process.“Deficiency Qi”is the pathological basis that leads to MIRI and is the foundation of its onset;“Stagnation”is the pathological key that leads to MIRI and is essential for its pathogenesis;the two are intertwined and mutually causal,ultimately forming a pathological state of“deficiency”and“stagnation”,with“deficiency”as the foundation and“stagnation”as the standard,accompanied by“deficiency”and“stagnation”.Therefore,this article is based on the basic theory of“deficiency qi stagnation”in traditional Chinese medicine,combined with mitochondrial dysfunction in modern medical mechanisms,to explore the correlation between the two in MIRI,comprehensively interpret the scientific connotation of the pathogenesis of“deficiency qi stagnation”,and provide new ideas and theoretical basis for the prevention and treatment of MIRI in traditional Chinese medicine.