调平归源法论治慢性萎缩性胃炎近远期临床疗效观察

Observation on the short-term and long-term clinical efficacy of the method of leveling and returning to the source in treating chronic atrophic gastritis

目的观察以“调平归源”为论治思想的脾胃培源方治疗慢性萎缩性胃炎的近远期疗效观察。方法收集从2018年1月至2022年1月在安徽中医药大学第二附属医院就诊治疗的CAG患者,其中100例通过脾胃培源方治疗,另外100例使用常规西药治疗。观察两组患者治疗前及12周后中医症候积分,24周后中医症候积分、胃镜病理积分、病理疗效等指标情况。结果中医症状积分:12周及24周治疗后两组中医症状积分均降低,差异有统计学意义,且治疗组均优于对照组(P<0.05);胃镜病理:24周治疗后两组各项评分均较前改善,差异有统计学意义,且治疗组效果更好(P<0.05);临床疗效:治疗组总有效率高于对照组(P<0.05)。两组均未有明显不良反应。结论基于“调平归源”法则的脾胃培源方能够改善CAG患者中医症状,缓解萎缩、肠化等病理表现,值得临床推广应用。

Objective To observe the short-term and long-term therapeutic effects of the Spleen and Stomach Peiyuan Formula in the treatment of chronic atrophic gastritis,which is based on the principle of"leveling and returning to the source".Methods Collect CAG patients who were treated at the Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine from January 2018 to January 2022.Among them,100 cases were treated with Spleen and Stomach Peiyuan Formula,and the other 100 cases were treated with conventional Western medicine.Observe the scores of traditional Chinese medicine symptoms before and after 12 weeks of treatment in two groups of patients,as well as thescores of traditional Chinese medicine symptoms,gastroscopy pathology,and pathological efficacy after 24 weeks.Results Traditional Chinese Medicine Symptom Score:After 12 and 24 weeks of treatment,the TCM symptom scores of both groups decreased significantly,and the difference was statistically significant,and the treatment group was better than the control group(P<0.05);Gastroscopy pathology:After 24 weeks of treatment,the scores of both groups improved significantly compared to before,and the treatment group had better results(P<0.05);Clinical efficacy:The total effective rate of the treatment group was higher than that of the control group(P<0.05).There were no adverse reactions in both groups.Conclusion Based on the rule of“Tiaoping Guiyuan method”,Spleen and Stomach Peiyuan Formula can improve symptoms of traditional Chinese medicine in CAG patients,relieve the pathological manifestations,such as atrophy and intestinal metaplasia and is worthy of clinical promotion and application.