肾移植患者感染COVID-19引起他克莫司血药浓度升高1例

Infection with COVID-19 in kidney transplant recipient with an elevated level of tacrolimus:one case report

肾移植患者长期使用免疫抑制剂,其感染COVID-19的风险增加。该例报告中,肾移植患者长期使用他克莫司(tacrolimus,TAC)预防排斥反应,感染COVID-19引起TAC血药浓度异常升高。通过文献复习,对造成TAC血药浓度升高的病理因素以及因TAC血药浓度升高导致的肝损伤、肾损伤等不良反应进行分析,为今后感染COVID-19的肾移植患者病理因素分析,以及TAC血药浓度异常引起的不良反应防治提供参考。

An elevated risk of COVID-19 is due to longterm use of immunosuppressants in kidney transplant(KT)recipients.In this report,one patient received tacrolimus(TAC)for a long time to prevent rejection.And COVID-19 caused an abnormal blood drug concentration of TAC.Patho⁃logical factors and adverse heptorenal reactions leading to an elevated level of TAC were examined through a literature review.It provided references for analyzing pathological fac⁃tors in COVID-19 KT recipients and preventing adverse reac⁃tions of an abnormal blood concentration of TAC.