乙型肝炎病毒感染患者的临床特征与预后的相关性

Retrospective analysis of clinical characteristics and prognosis of patients with hepatitis B virus infection

目的:回顾性分析乙型肝炎病毒感染(CHB)患者的临床特征与预后的相关性。方法:以2022年1月至2024年1月期间在郑州大学第五附属医院的CHB患者为研究对象,共入组152名CHB患者,以是否发生HBV-HCC为预后评价指标,对患者的临床特征进行了回顾和统计分析;通过对本研究患者的年龄、性别、吸烟史、酗酒、高脂血症、糖尿病史、PT、INR、AST、ALT、血小板、GGT、总胆红素、HBV DNA和肌酐等因素进行logistic回归分析,分析患者肝癌发生率的危险因素。接着采用ROC曲线寻找GGT对HBV-HCC的最佳预测阶段值,并验证GGT对患者患HCC的预测能力。结果:年龄、性别、吸烟史、嗜酒、糖尿病史、高血脂症、HBVDNA、PT、INR、血小板、AST、ALT、总胆红素以及肌酐(P>0.05),但GGT(P<0.001)、酗酒(P=0.004)、AST(P=0.007)、ALT(P=0.020)在两组间存在统计学差异(P<0.05);且多因素分析显示,GGT是HBV患者患HCC的危险因素(P<0.05);Pearson相关系数分析显示,GGT水平与HBV患者患HCC呈正相关(P<0.05);使用ROC曲线分析发现,当GGT水平最佳截断值为75U/L时,GGT预测HBV患者患HCC的AUC值为0.915。结论:GGT对HBV-HCC的最佳预截断段值为75 u/L,GGT对患者患HCC有预测价值。

Objective:To retrospectively analyze the clinical features and prognostic correlation of patients with hepatitis B virus infection.Methods:A total of 152 CHB patients admitted to the Fifth Affiliated Hospital of Zhengzhou University in China from January 2022 to January 2024 were enrolled.The clinical features of the patients were reviewed and statistically analyzed with the incidence of HBV-HCC as the prognostic index.logistic regression analysis was performed on the age,sex,smoking history,alcoholism,hyperlipidemia,diabetes history,PT,INR,AST,ALT,platelets,GGT,total bilirubin,HBV DNA and creatinine of the patients in this study to analyze the risk factors of HCC incidence.Then ROC curve was used to find the best predictive stage value of GGT for HBV-HCC,and to verify the predictive ability of GGT for patients with HCC.Results:Age,sex,smoking history,alcoholism,diabetes history,hyperlipidemia,HBV DNA,PT,INR,platelet,AST,ALT,total bilirubin and creatinine(P>0.05).However,GGT(P<0.001),alcoholism(P=0.004),AST(P=0.007)and ALT(P=0.020)were significantly different between the two groups(P<0.05).Multivariate analysis showed that GGT was a risk factor for HBV patients with HCC(P<0.05).Pearson correlation coefficient analysis showed that GGT level was positively correlated with HBV patients with HCC(P<0.05).ROC curve analysis showed that when the optimal cut-off value of GGT level was 75 U/L,the AUC value of GGT predicting HCC in HBV patients was 0.915.Conclusion:GGT is a risk factor associated with the prognosis of HBV patients.