幽门螺杆菌感染高危因素分析及其健康管理的探讨

Analysis of high-risk factors of Helicobacter pylori infection and discussion on health management

目的:分析健康体检人群幽门螺杆菌(Hp)感染的高危因素,从高危因素入手探讨其在Hp健康管理中的作用。方法:收集2023年1月至2023年12月至阜外华中心血管病医院健康管理中心体检并行^(13)C尿素呼气试验检查的人群资料,对比分析Hp感染组和Hp未感染组的年龄、性别、体质量指数(BMI)、血生化指标等的特征分布,筛查Hp感染的高危因素,针对高危因素提出健康管理新方法。结果:性别、年龄、总胆固醇在Hp感染组和Hp未感染组无明显差异(均P>0.05)。Hp感染组BMI、甘油三酯、低密度脂蛋白胆固醇、收缩压、舒张压、空腹血糖均显著高于Hp未感染组,且差异有统计学意义(均P<0.05)。Hp未感染组高密度脂蛋白胆固醇显著高于Hp感染组,差异也具有统计学意义(P<0.05)。二分类Logistic回归分析显示,超重、肥胖、高空腹血糖、高血压是Hp感染的危险因素。超重、肥胖、高空腹血糖、高血压1级、高血压2级、高血压3级的OR值及95%CI分别为1.094(95%CI1.005~1.191)、1.207(95%CI1.086~1.342)、1.053(95%CI 1.021~1.087)、1.153(95%CI1.046~1.271)、1.218(95%CI1.020~1.455)、1.525(95%CI1.105~2.105)。结论:“三高”增加Hp感染的风险,健康体检人群进行“三高”健康管理时,应养成良好的生活方式并定期筛查Hp,避免感染Hp。

Objective:To analyze the high risk factors of Helicobacter pylori infection in healthy people and explore its role in the health management of Hp.Methods:The data of the population who underwent physical examination and ^(13)C urea breath test at the Health Management Center of Fuwai Central China Cardiovascular Hospital was collected from January 2023 to December 2023.We analyze the characteristics of age,sex,BMI and blood biochemical indexes in the Hp infected group and the Hp uninfected group and screen the high risk factors of Hp infection and put forward a new method of health management.Results:There were no significant difference in gender,age and total cholesterol between Hp infected group and Hp uninfected group(P>0.05).The BMI,triglyceride,low density lipoprotein,systolic blood pressure,diastolic blood pressure and fasting blood glucose in Hp infected group were higher than those in non-Hp infected group and the differences were statistically significant(P<0.05).The high density lipoprotein in Hp uninfected group was higher than that in Hp infected group and the difference was statistically significant(P<0.05).Binary Logistic regression analysis showed that,overweight,obesity,fasting blood glucose and hypertension were risk factors for Hp infection.The OR values and 95%CI of overweight,obesity,high fasting glucose,grade 1 hypertension,grade 2 hypertension and grade 3 hypertension were 1.094(95%CI 1.005-1.191),1.207(95%CI 1.086-1.342),1.053(95%CI 1.021-1.087),1.153(95%CI 1.046-1.271),1.218(95%CI 1.020-1.455),1.525(95%CI 1.105-2.105).Conclusion:“Three high”increases the risk of Hp infection.When healthy people perform“three high”health management,they should develop a good lifestyle and regularly screen for Hp to avoid Hp infection.