HIF对固有淋巴细胞和T细胞的调控

Regulation of innate lymphoid cells and T cells by HIF

缺氧诱导因子(HIF)是一类调控细胞适应缺氧状态的关键分子,可在缺氧等因素的刺激下被激活,并入核发挥转录活性。在炎症和肿瘤等病理状态下,组织微环境往往处于缺氧状态。固有淋巴细胞(ILCs)和T淋巴细胞亚群作为抵御感染和抗肿瘤的重要效应细胞,其功能发挥受HIF蛋白调控。近年来,HIF家族蛋白HIF1α和HIF2α对ILCs和T细胞的调控作用的重要性日益彰显,为相关疾病机制的解读和治疗提供了新的思路。本文综述了HIF家族蛋白对ILCs和T细胞的调控作用及其机制的研究进展。

Hypoxia-inducible factor(HIF)are a family of molecules that are critical for regulating cellular adaptation to hypoxia,which can be activated by hypoxia and other stimuli,and then translocated into nucleus,where they modulate the transcription of target genes.Under the pathological conditions,such as inflammation and tumor,tissue microenvironment is often hypoxic.Innate lymphoid cells(ILCs)and T lymphocytes serve as important effector cells in defense against infection and tumor,and their functions are regulated by HIF proteins.In recent years,increasing evidence highlights the importance of HIF1αand HIF2α,two members of the HIF family,in regulating ILCs and T cells,providing new insights into mechanisms and treatment of diseases.This review summarizes the research progress on the role of HIF family proteins in ILCs and T cells and the underlying mechanisms.