CD4^(+)CD28^(−)T细胞的特点及其在疾病中的作用研究进展

Progress in research on characteristics of CD4^(+)CD28^(−)T cells and their roles in diseases

在健康的年轻人体内,传统CD4^(+)T细胞的CD28表达高达97.5%,而研究发现在老年人、慢性炎症和持续感染的患者体内CD4^(+)T细胞的CD28阳性率显著下降,甚至不足50%,即出现CD4^(+)CD28^(−)T细胞积累。CD4^(+)CD28^(−)T细胞是一群独特的CD4^(+)T细胞亚群,本文综述了该亚群的表型特征、功能特点及其在慢性病毒感染、自身免疫病和心血管疾病中的作用,为CD4^(+)CD28^(−)T细胞相关疾病的治疗和预后改善提供了新策略。

In healthy young people,the expression of CD28 in regular CD4^(+)T cells is 97.5%.However,studies have shown that in the elderly and patients with chronic inflammation and persistent infection,the positiveness of CD28 in CD4^(+)T cells decrease significantly,even less than 50%,that is,the accumulation of CD4^(+)CD28^(−)T cells.CD4^(+)CD28^(−)T cells are a unique subset of CD4^(+)T cells.In this review,we describes the characteristics of phenotype and function and their roles in chronic viral infections,autoimmune diseases,cardiovascular diseases of CD4^(+)CD28^(−)T cells,providing new strategies for the treatment and prognosis improvement of CD4^(+)CD28^(−)T cell-related diseases.