基于肠道菌群探讨多囊卵巢综合征的发病机制及中医药干预研究进展

Pathogenesis of Polycystic Ovary Syndrome and Its Research Progress of Traditional Chinese Medicine Intervention Based on Gut Microbiota

多囊卵巢综合征(PCOS)是一种以胰岛素抵抗、高雄激素血症、排卵功能异常等为主要表现的内分泌代谢紊乱性疾病,对育龄期女性造成了极大的身心困扰。近期研究表明,肠道菌群和PCOS的发病密切相关,同时中医药可通过调节靶向肠道菌群抑制PCOS的发生发展。因此,本文总结了肠道菌群在PCOS发展过程中的关键作用,并阐述了中医药基于肠道菌群多靶点、多途径防治PCOS的研究进展,以期为PCOS的治疗提供新思路。

Polycystic ovary syndrome(PCOS)is a kind of endocrine and metabolic disorder mainly manifested by insulin resistance,hyperandrogenemia and ovulation dysfunction,which causes great physical and mental disturbance to women of reproductive age.Recent studies have shown that intestinal flora is closely related to the pathogenesis of PCOS and traditional Chinese medicine compounds and their active ingredients can inhibit the occurrence and development of PCOS by targeting gut microbiota.Therefore,This paper summarizes the key role of intestinal flora in the development of PCOS,and expounds the research progress of TCM compounds and their monomers in the prevention and treatment of PCOS based on intestinal flora with multi-target and multi-approach,in order to provide new ideas for the treatment of PCOS.