黏蛋白MUC5AC在呼吸系统疾病中的研究进展

Research progress of mucin MUC5AC in respiratory diseases

气道黏液作为呼吸道抵抗吸入病原体和颗粒物损害的第一道先天防线,其主要固体成分是黏蛋白MUC5AC和MUC5B,其中MUC5AC被认为是最重要的一种。MUC5AC基因过表达是多种呼吸系统疾病的重要特征,包括慢性阻塞性肺疾病、支气管哮喘和囊性纤维化。MUC5AC基因的表达受多个方面的调节,包括转录水平、转录后水平、翻译后生物合成过程和表观遗传水平。本文对其调节机制及在呼吸系统疾病中的研究进展进行综述。

Airway mucus serves as the first innate defense of the respiratory tract against inhaled pathogens and invasion of particulate matters.Mucins MUC5AC and MUC5B are the major solid components of airway mucus,especially the former one.Overexpression of the MUC5AC is an important feature in a variety of respiratory diseases,including chronic obstructive pulmonary disease,asthma,and cystic fibrosis.Expression level of MUC5AC is multi-regulated at transcriptional,post-transcriptional,post-translational biosynthetic process and epigenetic levels.This article aims to review the regulatory mechanism and the progress of research on MUC5AC in respiratory diseases.