多糖纳米硒制备和生物活性研究进展

Research Progress in the Preparation and Biological Activity of Polysaccharide Nano-selenium

多糖纳米硒(Polysaccharide nano-selenium,Polysaccharide-SeNPs)具有独特的性质和生物学功能,在医学、食品和制药等研究领域具有无限的潜力和应用前景。本文主要从多糖、纳米硒和多糖纳米硒的结构和性质出发,阐述多糖与纳米硒二者之间的互补组合关系,纳米硒借助多糖分支结构中的羟基在其表面形成氢键或Se-O键,以达到分散和稳定的作用。本文对多糖纳米硒制备条件、方法及优化方式进行总结。目前,常用化学合成法制备多糖纳米硒,利用超声波、真空、高压或酶等辅助技术提高其产率或生物学活性。其次,归纳了近5年在国际上已发表具有代表性生物学作用的多糖纳米硒。本文着重论述多糖纳米硒在医学、食品、药品及保健品等相关研究领域的应用和进展。多糖纳米硒的研究为中药多糖及中医药学等领域拓宽了新的思路,为进一步探索新兴且具备高效生物学作用“硒”形貌提供了有利的参考依据。

Polysaccharide nano-selenium(polysaccharide selenium nanoparticles,Polysaccharide-SeNPs)exhibits unique properties and biological functions,offering limitless potential and promising applications in various fiels such as medicine,food and pharmacology.This review mainly focuses on the structure and properties of polysaccharides,nano-selenium(selenium nanoparticles,SeNPs)and the complementary combination of polysaccharides and SeNPs.SeNPs utilizes the hydrogen or Se-O bonds on its surface,thereby achieving dispersion and stability.The article provides a summary of the preparation conditions,methods,and optimization strategies for Polysaccharide-SeNPs.Currently,chemical synthesis methods are commonly used to produce Polysaccharide-SeNPs,with auxiliary techniques such as ultrasound,vacuum,high pressure,or enzymes employed to enhance yield or biological activity.Furthermore,the article reviews representative biological effects of Polysaccharide-SeNPs reported in the international literature over the past five years.Finally,emphasis is placed on the application and progress of Polysaccharide-SeNPs in the fields of medicine,food,pharmaceuticals,and health products.The study of Polysaccharide-SeNPs expands new perspectives in the field of traditional Chinese medicine,particularly polysaccharides derived from Chinese herbal medicine,providing a valuable reference for exploring novel and highly biologically active"selenium-shaped"entities.