缺氧与膀胱出口部分梗阻所致膀胱功能障碍的研究进展

Hypoxia and partial bladder outlet obstruction-caused bladder dysfunction:a review

膀胱出口部分梗阻(pBOO)可由良性前列腺增生等多种病因造成,持续性的pBOO会对膀胱结构与功能造成损害,即使解除梗阻患者仍会存在下尿路症状,降低患者生活质量且增加了医疗负担。膀胱缺氧是pBOO所致膀胱功能障碍(BD)的重要病理生理环节,缺氧介导的缺氧诱导因子信号在其中扮演重要角色,同时,缺氧造成的膀胱炎症、纤维化、血管新生等可进一步加重pBOO后膀胱损伤。目前,不少研究基于缺氧途径及其下游信号探索pBOO所致BD的干预治疗策略,已取得了一些进展。本文旨在对缺氧与pBOO所致BD的相关研究予以综述,并介绍相关的干预治疗策略。

Partial bladder outlet obstruction(pBOO)can be caused by various factors such as benign prostatic hyperplasia.Persistent pBOO can cause bladder structure and function damage.Even if the obstruction was relieved,patients will still have lower urinary tract symptoms,which reduced patients’quality of life and increased medical burden.Bladder hypoxia was an important pathophysiologic process in bladder dysfunction(BD)caused by pBOO.Hypoxia-mediated hypoxia inducible factor signaling played an important role in the process.Meanwhile,bladder inflammation,fibrosis,and angiogenesis,etc caused by hypoxia can further exacerbate bladder injury after pBOO.Currently,many studies had made some progress in exploring intervention and treatment strategies for pBOO-induced BD based on hypoxia pathways and downstream signals.This article aimed to review the relevant research on hypoxia and pBOO induced BD,and introduce relevant intervention and treatment strategies.