活血止痛胶囊配合功能锻炼治疗膝骨性关节炎的效果观察

Observation on the Effect of Huoxuezhitong Capsule Combined with Functional Exercise on Knee Osteoarthritis

目的:探讨与观察活血止痛胶囊配合功能锻炼治疗膝骨性关节炎的效果.方法:选择2022年6月—2023年5月吴堡县中医院和洛南县医院诊治的73例膝骨性关节炎患者为研究对象,依据随机掷硬币原则将73例患者分为中医组(n=37)和对照组(n=36).对照组给予功能锻炼治疗,中医组给予活血止痛胶囊配合功能锻炼治疗,2组都治疗并观察1个月,判定2组的治疗效果.结果:中医组治疗1个月后的总有效率高于对照组,差异有统计学意义(P<0.05).治疗1个月后,2组的膝关节Lysholm评分明显高于治疗前,且中医组膝关节Lysholm评分高于对照组,差异均有统计学意义(P<0.05).治疗1个月后,2组血清25-羟维生素D3含量均高于治疗前,且中医组血清25-羟维生素D3含量高于对照组,差异均有统计学意义(P<0.05).2组治疗1个月期间腹部不适、头晕、褥疮、静脉血栓、恶心呕吐等不良反应发生率对比,差异无统计学意义(P>0.05).结论:活血止痛胶囊配合功能锻炼治疗膝骨性关节炎,有助于提高患者的总体治疗效果,改善患者的膝关节功能,也可提高患者的血清25-羟维生素D3含量,且不会增加不良反应的发生率.

Objective:To explore and observe the effect of Huoxuezhitong capsule combined with functional exercise on knee osteoarthritis.Methods:73 patients with knee osteoarthritis diagnosed and treated in Wubao County Hospital of Traditional Chinese Medicine and Luonan County Hospital from June 2022 to May 2023 were selected as the study objects,and the 73 patients were divided into a TCM group(n=37)and a control group(n=36)according to the principle of random coin toss.The control group was given functional exercise treatment,and the traditional Chinese medicine group was given Huoxuezhitong capsule combined with functional exercise treatment.Both groups were treated and observed for 1 month to determine the therapeutic effect of the 2 groups.Results:The total effective rate of TCM group after 1 month was higher than that of control group,and the difference between groups was statistically significant(P<0.05).After 1 month of treatment,the knee Lysholm score of the 2 groups was significantly higher than that before treatment,and the knee Lysholm score of the Chinese medicine group was higher than that of the control group,with statistical significance(P<0.05).After 1 month of treatment,the serum 25-hydroxyvitamin D3 content of the 2 groups was higher than that before treatment,and the serum 25-hydroxyvitamin D3 content of the Chinese medicine group was higher than that of the control group,with statistical significance(P<0.05).There was no significant difference in the incidence of adverse reactions such as abdominal discomfort,dizziness,bedsore,venous thrombosis,nausea and vomiting between 2 groups during 1 month of treatment(P>0.05).Conclusion:Huoxuezhitong capsule combined with functional exercise for the treatment of knee osteoarthritis is helpful to improve the overall therapeutic effect of patients,improve the function of patients'knee joint,and also increase the serum 25-hydroxyvitamin D3 content of patients,without increasing the incidence of adverse reactions.