肝硬化患者Hp感染现状及危险因素分析

Current status and risk factors of Hp infection in liver cirrhosis patients

目的:探讨河南省肝硬化患者幽门螺杆菌(Hp)感染现状及其危险因素。方法:回顾性分析2021年12月至2023年6月河南省人民医院收治的200例肝硬化患者的临床资料,统计入组肝硬化患者实验室Hp阳性率,采用Logistic回归分析影响肝硬化患者Hp感染的危险因素。结果:入组200例肝硬化患者Hp感染率为64.00%(128/200)。单因素分析结果显示,性别、吸烟、合并糖尿病、合并高血压、尿酸、总胆固醇、高密度脂蛋白胆固醇、三酰甘油、肌酐、低密度脂蛋白胆固醇对肝硬化患者Hp感染的影响较小(P>0.05)。单因素和多因素分析结果显示,年龄≥60岁、饮酒、胃排空率<80%、血清CagA-IgG阳性、腹型肥胖和饮食辛辣或偏咸是肝硬化患者发生Hp感染的独立危险因素(P<0.05)。结论:肝硬化患者合并Hp感染发生率为64.00%,年龄≥60岁、饮酒、胃排空率<80%、血清CagA-IgG阳性、腹型肥胖和饮食辛辣或偏咸是肝硬化患者合并Hp感染的危险因素。

Objective:To investigate the current status and risk factors of Helicobacter pylori(Hp)infection in liver cirrhosis patients.Methods:The clinical data of 200 liver cirrhosis patients admitted to Henan Provincial People’s Hospital from December 2021 to June 2023 were retrospectively analyzed.The positive rate of Hp in the enrolled patients determined by the laboratory examination was statistically analyzed.The risk factors of Hp infection in liver cirrhosis patients were analyzed by logistic regression analysis.Results:Hp infection rate of the 200 cirrhosis patients was 64.00%(128/200).Results of univariate analysis showed that gender,smoking,diabetes,hypertension,uric acid,total cholesterol,high-density lipoprotein cholesterol,triacylglycerol,creatinine,low-density lipoprotein cholesterol had less effects on Hp infection in patients with liver cirrhosis(P>0.05).Results of univariate and multivariate analyzes showed that age≥60 years,alcohol drinking,gastric emptying rate<80%,serum CagA-IgG positive,abdominal obesity,and spicy or salty diet were independent risk factors for Hp infection in liver cirrhosis patients(P<0.05).Conclusions:The incidence of Hp infection in liver cirrhosis patients in Henan is 64.00%.Age≥60 years,alcohol drinking,gastric emptying rate<80%,serum CagA-IgG positive,abdominal obesity,and spicy or salty diet are risk factors for Hp infection in liver cirrhosis patients.