地塞米松磷酸钠联合布地奈德混悬液雾化吸入治疗小儿急性喉炎的效果观察

Observation on the therapeutic effect of dexamethasone sodium phosphate combined with nebulized budesonide inhalation suspension on acute laryngitis in children

目的:探讨地塞米松磷酸钠注射液联合布地奈德混悬液雾化吸入治疗小儿急性喉炎的临床效果。方法:队列研究。收集2023年3月至7月宝鸡市妇幼保健院收治的急性喉炎患儿119例,根据随机数字表法分为对照组(59例)和观察组(60例)。对照组采用地塞米松磷酸钠雾化吸入治疗,观察组在对照组基础上加用布地奈德混悬液雾化吸入治疗。比较两组治疗效果,炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]水平、临床相关指标及安全性。结果:观察组总有效率(96.67%,58/60)高于对照组(86.44%,51/59),P<0.05。治疗后,两组IL-6、TNF-α、CRP水平均较治疗前降低,且观察组低于对照组(P<0.05);观察组声音嘶哑、喉鸣音消失时间及住院时间均短于对照组(P均<0.05)。观察组不良反应总发生率(8.33%,5/60)与对照组(13.56%,8/59)比较差异未见统计学意义(P>0.05)。结论:急性喉炎患儿接受布地奈德混悬液雾化吸入治疗可提高治疗效果,降低炎症因子水平,缩短临床症状消失时间,且安全可靠。

Objective:To investigate the effect of dexamethasone sodium phosphate combined with nebulized budesonide inhalation suspension in the treatment of acute laryngitis in children.Methods:A cohort study was conducted on a total of 119 children with acute laryngitis admitted to Baoji Maternal and Child Health Hospital from March to July 2023.And they were divided into a control group(59 cases)and an observation group(60 cases)using a random number table method.The control group received dexamethasone sodium phosphate atomized inhalation,while the observation group received nebulized budesonide inhalation suspension based on the treatment of the control group.The therapeutic effects,levels of inflammatory factors,including interleukin-6,(IL-6),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP),clinical related indicators,and safety of the two groups were compared.Results:The total effective rate of the observation group(96.67%,58/60)was higher than that of the control group(86.44%,51/59),P<0.05.After treatment,the levels of IL-6,TNF-α,and CRP in both groups decreased compared with preoperative levels,and the above indicators in the observation group were lower than those in the control group(P<0.05).The disappearance time of symptoms(hoarseness,throat sounds)and hospital stay in the observation group were shorter than those in the control group(all P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the observation group(8.33%,5/60)and the control group(13.56%,8/59),P>0.05.Conclusions:Nebulized budesonide inhalation suspension can improve the therapeutic effect on acute laryngitis in children,reduce levels of inflammatory factors,and shorten the time for clinical symptom disappearance,which is safe and reliable.