柴胡加龙骨牡蛎汤联合五行音乐治疗非小细胞肺癌化疗后患者焦虑抑郁状态临床研究

Clinical Study on Chaihu and Longgu Muli Decoction Combined with Five Phases Music Therapy for Anxiety and Depression Status in Patients After Chemotherapy for Non-Small Cell Lung Cancer

目的:观察柴胡加龙骨牡蛎汤联合五行音乐治疗非小细胞肺癌化疗后患者焦虑抑郁状态的临床疗效。方法:选择78例非小细胞肺癌化疗后焦虑抑郁患者,根据随机数字表法分为观察组与对照组各39例。对照组给予西医常规治疗,观察组给予柴胡龙骨牡蛎汤联合五行音乐治疗。比较2组临床疗效,比较2组治疗前后贝克抑郁自评量表评分、抑郁自评量表(SDS)评分、汉密尔顿抑郁量表(HAMD)评分、焦虑自评量表(SAS)评分、汉密尔顿焦虑量表(HAMA)评分及血清5-羟色胺(5-HT)、γ-氨基丁酸(GABA)、胶质纤维酸性蛋白(GFAP)水平。结果:治疗后观察组总有效率为92.31%,高于对照组74.36%(P<0.05)。治疗后,2组贝克抑郁自评量表、SDS、HAMD评分均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗后,2组SAS、HAMA评分均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗后,2组血清5-HT、GABA水平均升高(P<0.05),且观察组高于对照组(P<0.05);2组血清GFAP水平降低(P<0.05),且观察组低于对照组(P<0.05)。结论:柴胡加龙骨牡蛎汤联合五行音乐可有效改善非小细胞肺癌化疗后患者焦虑抑郁状态,临床疗效显著。

Objective:To observe the clinical effect of Chaihu and Longgu Muli Decoction combined with five phases music therapy for anxiety and depression status in patients after chemotherapy for non�small cell lung cancer.Methods:A total of 78 cases of patients with anxiety and depression status after chemotherapy for non-small cell lung cancer were selected and divided into the observation group and the control group according to the random number table method,with 39 cases in each group.The control group was given conventional western medicine,and the observation group was treated with Chaihu and Longgu Muli Decoction combined with five phases music therapy.Clinical effects were compared between the two groups.The scores of Beck Depression Inventory,Self-rating Depression Scale(SDS),Hamilton Depression Rating Scale(HAMD),Self-rating Anxiety Scale(SAS)scores,and Hamilton Anxiety Rating Scale(HAMA),as well as the levels of serum 5-hydroxytryptamine(5-HT),γ-aminobutyric acid(GABA),and glial fibrillary acidic protein(GFAP)were compared between two groups before and after treatment.Results:After treatment,the total effective rate was 92.31%in the observation group,higher than that of 74.36%in the control group(P<0.05).After treatment,the scores of Beck Depression Inventory,SDS,and HAMD in the two groups were decreased(P<0.05),and the scores of Beck Depression Inventory,SDS,and HAMD in the observation group were lower than those in the control group(P<0.05).After treatment,the scores of SAS and HAMA in the two groups were decreased(P<0.05),and the scores of SAS and HAMA in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of serum 5-HT and GABA in the two groups were increased(P<0.05),and the levels of serum 5-HT and GABA in the observation group were higher than those in the control group(P<0.05);levels of serum GFAP in the two groups were declined(P<0.05),and the level of serum GFAP in the observation group was lower than that in the control group(P<0.05).Conclusion:Chaihu and Longgu Muli Decoction combined with five phases music therapy can effectively improve the anxiety and depression status in patients after chemotherapy for non-small cell lung cancer,with significant clinical effects.