足浴疗法对肾病综合征瘀血证患者凝血功能的影响

Effect of Foot Bath Therapy on Coagulation Function in Patients with Nephrotic Syndrome with Blood Stasis Syndrome

目的:观察足浴疗法对肾病综合征瘀血证患者凝血功能的影响。方法:选取70例肾病综合征患者,按随机数字表法分为治疗组及对照组各35例。对照组接受抗凝治疗,治疗组在对照组基础上采用中药足浴疗法治疗。比较2组临床疗效,比较2组治疗前后凝血指标[凝血酶原时间(PT)、国际化标准比值(INR)、部分凝血酶原时间(APTT)、纤维蛋白原(FIB)、凝血酶时间(TT)、D-二聚体(DD)、PT正常对照值]、肾功能指标[血尿氮素(BUN)、血清肌酐(SCr)、血白蛋白、尿蛋白定量]的变化。结果:治疗组临床疗效为94.29%,对照组为80.00%,2组临床疗效比较,差异有统计学意义(P<0.05)。治疗后,2组PT、INR、APTT、DD、PT正常对照值水平组内、组间比较,差异无统计学意义(P>0.05)。治疗后,2组FIB、TT水平均较治疗前下降(P<0.05),治疗组FIB、TT水平均低于对照组(P<0.05)。治疗后,2组尿蛋白定量、BUN、SCr水平均较治疗前下降(P<0.05),血白蛋白水平均较治疗前升高(P<0.05);治疗组尿蛋白定量、BUN、SCr水平均低于对照组(P<0.05),血白蛋白水平高于对照组(P<0.05)。结论:足浴疗法治疗肾病综合征瘀血证能够改善患者高凝状态和肾功能指标值,辅助抗凝治疗。

Objective:To observe the effect of foot bath therapy on coagulation function in patients with nephrotic syndrome with blood stasis syndrome.Methods:A total of 70 cases of patients with nephrotic syndrome were selected and divided into the treatment group and the control group by random number table method,with 35 cases in each group.The control group received anticoagulant therapy,and the treatment group was additionally treated with foot bath therapy based on the treatment of the control group.Clinical effects were compared between the two groups.The changes in coagulation index values[prothrombin time(PT),Prothrombin Time and International Normalized Ratio(INR),activated partial thromboplastin time(APTT),fibrinogen(FIB),thrombin time(TT),D-dimer(DD),and PT normal control value],renal function index values[blood urea nitrogen(BUN),serum creatinine(SCr),blood albumin,and urine protein quantification]were compared before and after treatment between the two groups.Results:The total clinical effective rate was 94.29%in the treatment group and 80.00%in the control group,the difference being significant(P<0.05).After treatment,there was no significant difference inintra-group and inter-group comparison of PT,INR,APTT,DD,and PT normal control value between the two groups(P>0.05).After treatment,the index values of FIB and TT in the two groups were decreased when compared with those before treatment(P<0.05),and the index values of FIB and TT in the treatment group were lower than those in the control group(P<0.05).After treatment,the levels of urinary protein quantification,BUN,and SCr in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of blood albumin were increased(P<0.05);the levels of urinary protein quantification,BUN,and SCr in the treatment group were lower than those in the control group(P<0.05),and the level of blood albumin in the treatment group was higher than that in the control group(P<0.05).Conclusion:Foot bath therapy can improve the hypercoagulable state and renal function index values of patients with nephrotic syndrome with blood stasis syndrome,and assist anticoagulant therapy.