改良通窍活血汤联合喹硫平治疗对双相情感障碍患者血液生化指标的影响

Effect of Modified Tongqiao Huoxue Decoction Combined with Quetiapine on Blood Biochemical Indexes of Patients with Bipolar Disorder

目的:探究改良通窍活血汤联合喹硫平治疗对双相情感障碍患者血液生化指标的影响。方法:选取2021年7月—2023年12月在江西省精神病院治疗的80例双相情感障碍患者,按照随机数字表法将患者分为对照组和观察组,各40例。对照组采用喹硫平,观察组在对照组基础上加用改良通窍活血汤。比较两组临床效果、认知功能、心理状态、阳性和阴性精神症状评定量表(PANSS)、药物副反应量表(TESS)及血液生化指标。结果:观察组临床总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组心理状态评分、认知功能评分、血液生化指标水平、PANSS评分均较治疗前改善,观察组均优于对照组(P<0.05)。治疗后,观察组TESS评分低于对照组,差异有统计学意义(P<0.05)。结论:改良通窍活血汤联合喹硫平治疗对双相情感障碍患者的效果较好,可改善认知功能、心理状态、症状量表、副反应情况,调节机体血清生化指标水平。

Objective:To explore the effects of Modified Tongqiao Huoxue Decoction combined with Quetiapine on blood biochemical indexes in patients with bipolar disorder.Method:A total of 80 patients with bipolar disorder treated in Jiangxi Mental Hospital from July 2021 to December 2023 were selected,and were divided into control group and observation group according to random number table method,with 40 patients in each group.The control group was treated with Quetiapine,and the observation group was treated with Modified Tongqiao Huoxue Decoction on the basis of control group.The clinical effect,cognitive function,mental state,positive and negative syndrome scale(PANSS),treatment emergent symptom scale(TESS)and blood biochemical indexes were compared between the two groups.Result:The clinical total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,psychological status scores,cognitive function scores,blood biochemical indexes and PANSS scores of both groups were significantly improved compared to those before treatment,and those in the observation group were better than those in the control group,the differences were statistically significant(P<0.05).After treatment,TESS score of observation group was lower than that of control group,the difference was statistically significant(P<0.05).Conclusion:Modified Tongqiao Huoxue Decoction combined with Quetiapine can improve the cognitive function,mental state,symptom scale,side effects and regulate the levels of serum biochemical indexs in patients with bipolar disorder.