原发性醛固酮增多症患者靶器官损害的研究进展

Research Progress of Target Organ Damage in Patients with Primary Aldosteronism

原发性醛固酮增多症(primary aldosteronism,PA)是继发性高血压最常见的原因,PA主要通过醛固酮激活盐皮质激素受体(mineralocorticoid receptor,MR)导致靶器官损害,如:心血管、肾脏、脑损害及代谢紊乱等。通过了解PA患者靶器官损害的临床特点和发生机制,可引起临床医师对PA的重视,有利于改善患者的预后,本文就PA患者靶器官损害的相关研究进行综述。

Primary aldosteronism(PA)is the most common cause of secondary hypertension.PA mainly activates the mineralocorticoid receptor(MR)through aldosterone,leading to target organ damage,such as cardiovascular,renal,cerebral damage and metabolic disorders.By understanding the clinical characteristics and mechanisms of target organ damage in patients with PA,can draw the attention of clinicians to PA,which is conducive to improving the prognosis of patients,and this article reviews the relevant studies on target organ damage in patients with PA.