雾化吸入药代动力学试验护理配合的经验总结与探讨

Experience summary and discussion on nursing collaboration in pharmacokinetic trials of nebulized inhalation formulations

目的 总结雾化吸入制剂药代动力学试验中健康受试者的规范化用药管理流程,探讨护理配合要点.方法 针对中山大学孙逸仙纪念医院开展的一项雾化吸入制剂的改良型新药药代动力学研究的试验过程展开回顾性分析与探讨.结果 操作一致性、受试者的配合、环境控制以及用药剂量监测等因素是雾化制剂药代动力学试验护理管理的关键及难点.结论 研究护士的规范化给药过程及护理配合是保证雾化吸入药代动力学试验顺利完成的重要环节,进一步为临床试验提供更准确的数据.

Objective To summarize the standardized medication management process for healthy subjects in pharmacokinetic trials of nebulized inhalation formulations and explore key nursing collaboration points.Methods A retrospective analysis and discussion were conducted on the trial process of a new drug,which underwent formulation improvement to a nebulized inhalation formulation,in pharmacokinetic research conducted at our institution.Results Factors such as operational consistency,subject cooperation.environmental control,and medication dose monitoring were identified as key challenges in the nursing management of pharmacokinetic trials involving nebulized formulations.Conc lusion Standardized medication administration processes and nursing collaboration are crucial for ensuring the smooth completion of pharmacokinetic trials involving nebulized inhalation,further enhancing the accuracy of data for clinical trials.