经皮导入复方甘草酸苷溶液对玫瑰痤疮的临床治疗效果

Clinical effects of percutaneous introduction of compound ammonium glycyrrhizin solution in the treatment of acne rosacea

目的评估经皮导入复方甘草酸苷溶液治疗红斑毛细血管扩张型玫瑰痤疮的临床效果和安全性。方法将75例红斑毛细血管扩张型玫瑰痤疮患者随机分为3组,治疗A组27例患者予以经皮导入复方甘草酸苷溶液联合外用医用冷敷敷料,治疗B组25例患者予以口服复方甘草酸苷片联合外用医用冷敷敷料,对照组23例患者仅外用医用冷敷敷料。3组患者的治疗周期均为4周。结果治疗结束后,3组疗效比较,差异具有统计学意义(P<0.05)。治疗A组在试验过程中有2例出现症状一过性加重,予以脱落试验。在3组患者的整个治疗过程中,未出现严重不良反应。在治疗结束后1个月的随访中,3组复发率比较,差异无统计学意义(P>0.05)。结论经皮导入复方甘草酸苷溶液治疗红斑毛细血管扩张型玫瑰痤疮在临床上安全有效。

Objective To evaluate the clinical efects and safety of percutaneous introduction of compound ammonium glycyrrhizin solution in the treatment of erythema telangiectasia acne rosacea.Methods 75 patients with erythema telangiectasia rose acne were randomly divided into 3 groups.Group A(27 cases)were treated with compound ammonium glycyrrhizin solution combined with external medical cold dressing.Group B(25 cases)were treated with oral compound ammonium glycyrrhizin tablets combined with external medical cold dressing,and the control group(23 cases)were treated with external medical cold dressing only.The treatment cycle of the 3 groups was 4 weeks.Results After treatment,the efficacy of the 3 groups was compared,and the difference was statistically significant(P<0.05).During the trial,2 cases in Group A were experienced transient worsening of symptoms and were subjected to dropout testing.Throughout the treatment process of the three groups of patients,no serious adverse reactions occurred.During the one month follow-up after treatment,there was no statistically significant difference in recurrence rates among the three groups(P>0.05).Conclusion Percutaneous introduction of compound ammonium glycyrrhizin solution in the treatment of erythema telangiectasia rose acne is clinically safe and effective.