血液检测指标在IgG4-RD合并骨质疏松中的临床价值

Clinical value of blood testing indicators in IgG4-RD combined with osteoporosis

目的观察血液检测指标在IgG4相关性疾病(IgG4-RD)合并骨质疏松的变化情况。方法将26例IgG4-RD患者和51例健康者分别作为IgG4-RD组和对照组,分别对两组进行血常规和凝血项目检测并分析;将26例IgG4-RD患者进一步分为5例骨质疏松组和21例无骨质疏松组进行血常规和凝血项目检测并分析。结果IgG4-RD患者的红细胞分布宽度与白细胞数的测得值、单核细胞比值、未成熟粒细胞比值、单核细胞绝对值、中性粒细胞绝对值、未成熟粒细胞绝对值、凝血酶时间的测得值、D-二聚体的水平均较健康者升高,差异具有统计学意义(P<0.05);IgG4-RD患者的红细胞数、血红蛋白浓度、红细胞压积、平均红细胞体积、平均血红蛋白量、平均血红蛋白浓度、血小板体积分布宽度的测得值,以及淋巴细胞比值、嗜碱性粒细胞比值均较健康者低(P<0.05)。IgG4-RD合并骨质疏松组患者红细胞分布宽度测的测得值和有核红细胞绝对值均较无骨质疏松组高(P<0.05)。结论IgG4相关疾病患者多项血液指标发生改变,这些改变提示存在免疫失调的情况,可以作为IgG4相关疾病和IgG4合并骨质疏松的诊断和治疗依据。

Objective To observe the clinical value of blood routine and coagulation parameters in IgG4-related disease(IgG4-RD)with osteoporosis.Methods 26 patients diagnosed with IgG4-RD and 51 healthy controls were selected as the IgG4-RD group and control group,respectively.Blood routine and coagulation tests were performed and analyzed for both groups.26 IgG4-RD patients were further divided into the osteoporosis groups(5 cases)and non osteoporosis groups(21 cases)for blood routine and coagulation tests and analysis.Results The measured values of red blood cell distribution width and white blood cell count,monocyte ratio,immature granulocyte ratio,absolute values of monocytes,absolute values of neutrophils,absolute values of immature granulocytes,measured values of thrombin time,and D-dimer levels in IgG4-RD patients were higher than those in healthy individuals,showing a statistically significant difference(P<0.05).The measured values of red blood cell count,hemoglobin concentration,hematocrit,mean red blood cell volume,mean hemoglobin quantity,mean hemoglobin concentration,platelet volume distribution width,as well as lymphocyte ratio and eosinophil ratio in IgG4-RD patients were lower than those in healthy individuals(P<0.05).The measured values of red blood cell distribution width and absolute values of nucleated red blood cells in patients with IgG4-RD combined with osteoporosis were higher than those in the non osteoporosis group(P<0.05).Conclusion Multiple indicators in blood routine and coagulation function have changed in patients with IgG4-RD,indicating the presence of immune dysfunction,which may serve as a diagnostic and therapeutic basis for IgG4-RD and IgG4-associated osteoporosis.