甲苯磺酸芦玛哌酮联合重复经颅磁刺激治疗精神分裂症疗效及对血清学指标的影响

Efficacy of lumateperone tosylate plus repetitive transcranial magnetic stimulation in schizophrenia and its influence on serological indicators

目的探讨甲苯磺酸芦玛哌酮联合重复经颅磁刺激(rTMS)治疗精神分裂症疗效及对血清学指标的影响。方法将80例精神分裂症患者按照随机数字表法分为观察组和对照组,各40例。对照组患者采用甲苯磺酸芦玛哌酮治疗,观察组患者在对照组基础上联合rTMS治疗。比较治疗前后两组患者阳性和阴性症状量表(PANSS)评分及血清S100钙结合蛋白B(S100B)、中枢神经特异性蛋白β(S100β)、中间丝相关蛋白(Repetin)水平,比较两组患者治疗后临床疗效及不良反应总发生率。结果治疗后,观察组患者PANSS总分及阴性症状、阳性症状、精神病理维度评分均低于治疗前,且PANSS总分及阴性症状维度评分均低于对照组(P<0.05或0.01)。治疗后,观察组患者临床疗效总有效率高于对照组(P<0.01)。治疗后,两组患者血清S100B、S100β水平均较治疗前下降,Repetin水平升高(P<0.05或0.01);观察组患者血清S100B、S100β水平低于对照组,Repetin水平高于对照组(P<0.01)。两组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论甲苯磺酸芦玛哌酮联合rTMS治疗精神分裂症患者的疗效良好,可缓解患者的临床症状,调节血清S100B、S100β和Repetin水平,预后良好,值得临床推广。

Objective To explore the efficacy of lumateperone tosylate plus repetitive transcranial magnetic stimulation(rTMS)in schizophrenia and its influence on serological indicators.Methods Eighty schizophrenics were divided into observation and control group according to random number table,with 40 ones in each.Controls were treated with lumateperone tosylate,observation group was plus the rTMS on the basis of controls.The Positive and Negative Syndrome Scale(PANSS)scores and the levels of S100 calbindin B serum astrologic glial protein(S100B),central nervous system specific proteinβcalbindin(S100β)and intermediate filament-associated protein(Repetin)were compared between two groups before and after treatment,so were done the clinical efficacy and the total incidence of adverse reactions.Results After treatment the total,negative symptom,positive symptom and psychopathological dimension score of the PANSS were lower compared with pre-treatment in observation group,so were the total and negative symptom in observation than control group(P<0.05or 0.01).After treatment the total effective rate was higher in observation than control group(P<0.01).After treatment the serum S100B and S100βlevels decreased and Repetin increased in both groups compared with pre-treatment(P<0.05 or 0.01),the serum S100B and S100βlevel were lower and Repetin was higher in observation than control group(P<0.01).Intergroup difference in total incidence of adverse reactions wasn't statistically significant(P>0.05).Conclusion Lumateperone tosylate+rTMS in schizophrenics has good efficacy,can alleviate clinical symptoms,regulate peripheral blood S100B,S100β,and Repetin level,has good prognosis,and it is worthy of clinical promotion.