青少年女性抑郁症患者生化指标与焦虑抑郁及自杀意念的相关性分析

Correlation of biochemical indicators with anxiety,depression and suicidal ideation in female adolescents with depression

目的探究青少年女性抑郁症患者生化指标与焦虑、抑郁及自杀意念量表评分的相关性。方法选取12~18岁女性抑郁症患者为研究对象,将50例有自杀意念者作为研究组,50例无自杀意念者作为对照组。采用汉密顿焦虑量表(HAMA)、汉密顿抑郁量表(HAMD)、Beck自杀意念量表中文版(BSI-CV)对两组患者进行评定,检测两组患者空腹血糖、血脂四项[血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、甲状腺功能五项[促甲状腺激素(TSH)、三碘甲状腺原氨酸(T3)、游离三碘甲状腺原氨酸(FT3)、甲状腺素(T4)、游离甲状腺素(FT4)]及性激素六项[卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、孕酮(P)、睾酮(T)及催乳素(PRL)]等生化指标,并分析上述生化指标与HAMA、HAMD及BSI-CV评分的相关性。结果研究组患者TC、LH水平高于对照组,HDL-C水平低于对照组(P<0.05)。研究组患者BSI-CV评分高于对照组(P<0.01)。研究组患者血糖水平与HAMD评分呈正相关(P<0.05),HDL-C、E2水平与HAMD及BSI-CV评分呈负相关(P<0.05)。HDL-C水平是焦虑、抑郁的保护因素(P<0.05);E2水平是焦虑、抑郁及自杀意念的保护因素(P<0.05或0.01)。结论女性青少年抑郁症患者的HDL-C及E2水平与其焦虑、抑郁严重程度及自杀意念有关,临床实践除需关注其症状外,还需关注HDL-C及E2等生化指标的变化。

Objective To explore the correlation of biochemical indicators of female adolescents with depression with the scores on anxiety,depression,and suicidal ideation scales.Methods Female patients with depression aged 12~18 years were selected as research objects,50 ones with suicidal ideation as research group,and 50 without as control group.Patients of both groups were evaluated using Hamilton An xiety Scale(HAM A),Hamilton Depression Scale(HAMD)and Beck Scale for Suicide IdeationChinese Version(BSI-CV),such biochemical indicators detected as fasting blood glucose(FBG),four items of blood lipids(TC/TG/HDL-C/LDL-C),five items of thy roid functions(TSH/T3/FT3/T4/FT4)and six items of sex hormones(FSH/LH/E2/P/T/PRL),and the correlations of above-mentioned biochem icalind icators wit h the scores on HAMA,HAMD a nd BSI-CV ana lyzed.Results Tot alserum cholesterol and luteinizing hor mone level were higher and high density lipoprotein cholesterol(HDL-C)was lower in research than control group(P<0.05).The score on the BSI-CV was higher in research than control group(P<0.01).Blood glucose levels were positively correlated with HAMD score(P<0.05)in research group,HDL-C and estradiol(E2)negatively with HAMD and BSI-CV(P<0.05)in research group.HDL-C level was protective factor of anxiety and depression(P<0.05),E2 protective factor of anxiety,depression and suicidal ideation(P<0.05 or 0.01).Conclusion HDL-C and E2 level of female adolescents with depression are related to the severity of anxiety and depression as well as suicidal ideation,in clinical practice it is necessary to pay attention to the changes of biochemical indicators of HDL-C and E2 etc.in addition to symptoms.