补肾活血汤联合低能量冲击波治疗肾虚血瘀型勃起功能障碍的效果

Effect of Bushen Huoxue Decoction Combined with Low Energy Shock Wave on Erectile Dysfunction of Kidney Deficiency and Blood Stasis Type

目的:探讨补肾活血汤联合低能量冲击波治疗肾虚血瘀型勃起功能障碍的效果。方法:采用随机对照试验研究,依据随机数字表法将南昌市生殖医院2022年1月—2023年12月收治的86例肾虚血瘀型勃起功能障碍患者分为对照组和观察组,各43例。对照组在常规治疗基础上给予低能量冲击波治疗,观察组在对照组基础上加用补肾活血汤治疗,持续治疗6周。比较两组治疗前后的勃起功能、中医证候评分、性激素水平及血管内皮功能。结果:治疗后,两组国际勃起功能指数-5(IIEF-5)评分、勃起硬度等级(EHS)评分均较治疗前升高,两组中医证候评分均较治疗前降低,且观察组IIEF-5、EHS评分均高于对照组,中医证候评分均低于对照组,差异均有统计学意义(P<0.05);治疗后,两组内皮素-1(ET-1)水平均较治疗前降低,黄体生成素(LH)、睾酮(T)、一氧化氮(NO)水平均较治疗前升高,且观察组ET-1水平低于对照组,LH、T、NO水平均高于对照组,差异均有统计学意义(P<0.05)。结论:补肾活血汤联合低能量冲击波治疗肾虚血瘀型勃起功能障碍效果显著,可减轻勃起障碍程度,增强勃起硬度,同时还可改善性激素水平及血管内皮功能。

Objective:To explore the effect of Bushen Huoxue Decoction combined with low energy shock wave therapy on erectile dysfunction of kidney deficiency and blood stasis type.Method:A randomized controlled trial was conducted.According to the random number table method,86 patients with erectile dysfunction of kidney deficiency and blood stasis type admitted to Nanchang Reproductive Hospital from January 2022 to December 2023 were divided into control group and observation group,with 43 cases in each group.The control group was treated with low energy shock wave on the basis of conventional treatment,and the observation group was treated with Bushen Huoxue Decoction on the basis of the control group,continuous treatment for 6 weeks.The erectile function,traditional Chinese medicine syndrome scores,sex hormone levels,and vascular endothelial function were compared between the two groups before and after treatment.Result:After treatment,the international index of erectile function-5(IIEF-5)scores and erectile hardness scale(EHS)scores of both groups increased compared to those before treatment,while the TCM syndrome scores of both groups were decreased compared to those before treatment,the IIEF-5 and EHS scores of the observation group were higher than those of the control group,while the TCM syndrome scores were lower than those of the control group,the differences were statistically significant(P<0.05).After treatment,the levels of endothelin-1(ET-1)in both groups were decreased compared to those before treatment,while the levels of luteinizing hormone(LH),testosterone(T),and nitric oxide(NO)were increased compared to those before treatment,the level of ET-1 in the observation group was lower than that in the control group,while the levels of LH,T and NO were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:The combination of Bushen Huoxue Decoction and low energy shock wave has a significant therapeutic effect on erectile dysfunction of kidney deficiency and blood stasis type.It can reduce the degree of erectile dysfunction,enhance erection hardness,and also improve sexual hormone levels and vascular endothelial function.