内镜下黏膜切除术与高频电凝电切术治疗结肠巨大息肉效果及安全性分析

Analysis of the Effect and Safety of Endoscopic Mucosal Resection and High-frequency Electric Coagulation and Electrocision in the Treatment of Giant Polyps of Colon

目的:探究内镜下黏膜切除术(EMR)治疗结肠巨大息肉的效果。方法:选择2019年5月—2022年5月在大连市第三人民医院进行治疗的110例结肠巨大息肉患者,应用随机数字表法将其分为对照组(行高频电凝电切术)及研究组(行EMR),各55例。对比两组临床指标(手术时间、住院时间)、临床疗效、应激反应[肾上腺素(E)、去甲肾上腺素(NE)、皮质醇(Cor)]、炎症反应[白细胞介素-6(IL-6)、白细胞介素-12(IL-12)、白细胞介素-1β(IL-1β)]、并发症发生情况。结果:研究组手术时间、住院时间均短于对照组,差异均有统计学意义(P<0.05)。研究组临床疗效优于对照组,差异有统计学意义(P<0.05)。与术前比较,术后两组E、NE、Cor均升高,研究组上述指标均低于对照组,差异均有统计学意义(P<0.05)。与术前比较,术后两组IL-6、IL-12、IL-1β均升高,研究组上述指标均低于对照组,差异均有统计学意义(P<0.05)。研究组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论:结肠巨大息肉患者行EMR治疗,可提高临床疗效,减轻炎症反应、应激反应,减少并发症发生,促进康复。

Objective:To investigate the effect of endoscopic mucosal resection(EMR)in the treatment of giant polyps of colon.Method:A total of 110 patients with giant polyps of colon who were treated in Dalian NO.3 People's Hospital from May 2019 to May 2022 were selected and divided into the control group(received highfrequency electric coagulation and electrocision)and the study group(received EMR)by random number table method,with 55 cases in each group.Clinical indexes(operative time,hospital stay),clinical efficacy,stress response[epinephrine(E),norepinephrine(NE),cortisol(Cor)],inflammatory reaction[interleukin-6(IL-6),interleukin-12(IL-12),interleukin-1β(IL-1β)]and complications were compared between the two groups.Result:The operation time and hospital stay of the study group were shorter than those of the control group,the differences were statistically significant(P<0.05).The clinical efficacy of the study group was better than that of the control group,the difference was statistically significant(P<0.05).Compared with those before operation,E,NE and Cor were increased in both groups after operation,and the above indexes in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).Compared with those before operation,IL-6,IL-12 and IL-1βwere increased in both groups after operation,the above indexes in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of complications of the study group was lower than that of the control group,the difference was statistically significant(P<0.05).Conclusion:EMR treatment for patients with giant polyps of colon can improve clinical efficacy,reduce inflammation reaction and stress response,reduce complications and promote rehabilitation.