伏格列波糖联合西格列汀治疗T2DM对患者胰岛素抵抗的影响

Effect of Combined Treatment with Voglibose and Sitagliptin on Insulin Resistance in Patients with T2DM

目的:观察伏格列波糖联合西格列汀治疗2型糖尿病(T_(2)DM)对患者胰岛素抵抗的影响。方法:将贵溪市人民医院2021年1月—2023年9月收治的80例T_(2)DM患者随机分组,其中治疗组40例,对照组40例,治疗组采用伏格列波糖联合西格列汀治疗,对照组单用西格列汀治疗。均治疗两个月,比较两组治疗前后血糖水平[空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)]、治疗前后胰岛素功能[空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、胰岛素β细胞功能指数(HOMA-β)]、治疗后临床疗效及不良反应。结果:治疗后,两组FBG、2 h PG、HbA1c水平均显著降低(P<0.05),且治疗组均低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组FINS、HOMA-IR水平均显著降低,HOMA-β水平均显著升高(P<0.05),且治疗组均优于对照组,差异均有统计学意义(P<0.05)。治疗组的总有效率高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:伏格列波糖联合西格列汀治疗T_(2)DM可显著降低患者血糖水平,有效改善胰岛素抵抗,整体效果突出,且安全性较高。

Objective:To observe the effect of combined treatment with Voglibose and Sitagliptin on insulin resistance in patients with type 2 diabetes mellitus(T_(2)DM).Method:From January 2021 to September 2023,80 patients with T_(2)DM admitted to Guixi People's Hospital were selected as the subjects.They were randomly assigned to the treatment group and the control group,with 40 cases in each group.The treatment group was treated with Voglibose combined with Sitagliptin,while the control group was treated with Sitagliptin alone.All patients were treated for two months.The two groups were compared on blood glucose[fasting blood glucose(FBG),2-hour postprandial blood glucose(2 h PG)and glycated hemoglobin(HbA1c)],insulin function[fasting insulin(FINS),insulin resistance index(HOMA-IR)and insulin beta-cell function(HOMA-β)]before and after treatment,clinical effects,and adverse reactions.Result:After treatment,the levels of FBG,2 h PG and HbA1c in the two groups were significantly decreased(P<0.05),and those in the treatment group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of FINS and HOMA-IR in the two groups were significantly decreased,and the levels of HOMA-βwere significantly increased(P<0.05),and those in the treatment group were better than those in the control group,the differences were statistically significant(P<0.05).The total effective rate of the treatment group was higher than that of the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combined treatment with Voglibose and Sitagliptin can significantly reduce blood glucose levels and effectively improve insulin resistance in patients with T_(2)DM,the overall effect is outstanding,and the safety is high.