呼吸系统感染患者血清降钙素原的检测价值研究

Study on the value of serum procalcitonin in patients with respiratory infection

目的分析呼吸系统感染患者降钙素原的检测价值。方法将50例呼吸系统感染患者作为感染组,另将50例健康体检者作为参考组;两组均接受血液检测。将感染组患者根据疾病严重程度分为轻症组、重症组,各25例;两组均按要求实施抗感染治疗,治疗后再次实施血液检验。比较感染组和参考组降钙素原、C反应蛋白及白细胞计数;比较轻症组和重症组降钙素原、C反应蛋白及白细胞计数;比较降钙素原、C反应蛋白及白细胞计数检测对呼吸系统感染的阳性检出率;比较感染组治疗前后降钙素原、C反应蛋白及白细胞计数;比较轻症组和重症组治疗前后降钙素原、C反应蛋白及白细胞计数。结果感染组降钙素原(20.23±5.03)ng/ml、C反应蛋白(60.90±21.04)mg/L及白细胞计数(20.88±3.71)×10^(9)/L均明显高于参考组的(0.49±0.18)ng/ml、(5.08±0.72)mg/L、(6.04±1.25)×10^(9)/L(P<0.05)。重症组降钙素原(33.05±8.21)ng/ml、C反应蛋白(98.76±16.35)mg/L及白细胞计数(29.74±3.35)×10^(9)/L均明显高于轻症组的(7.41±1.98)ng/ml、(23.04±7.82)mg/L、(12.01±2.57)×10^(9)/L(P<0.05)。降钙素原检测对呼吸系统感染的阳性检出率为96.00%,高于C反应蛋白检测的80.00%和白细胞计数检测的74.00%(P<0.05);C反应蛋白检测对呼吸系统感染的阳性检出率与白细胞计数检测比较差异无统计学意义(P>0.05)。治疗后,感染组降钙素原(6.53±2.01)ng/ml、C反应蛋白(8.21±1.24)mg/L及白细胞计数(8.64±1.33)×10^(9)/L均明显低于治疗前(P<0.05)。治疗后,轻症组和重症组降钙素原、C反应蛋白及白细胞计数均低于治疗前(P<0.05)。结论呼吸系统感染患者检测降钙素原,不仅能确诊感染情况,而且还能了解感染程度,可对治疗方案提供参考依据,还可评估预后。

Objective To analyze the value of value of serum procalcitonin in patients with respiratory infection.Methods 50 patients with respiratory infections were taken as the infection group,and another 50 healthy subjects were taken as the reference group;Both groups received blood tests.The patients in the infected group were divided into a mild group and a severe group according to the severity of the disease,with 25 cases in each group;both groups were subjected to anti-infective treatment according to the requirements,and the blood tests were performed again after the treatment.Comparison of procalcitonin,C-reactive protein and white blood cell count between the infection group and the reference group,as well as between the mild group and severe group;comparison of the positive detection rate of respiratory infections by procalcitonin,C-reactive protein and white blood cell count;comparison of procalcitonin,C-reactive protein and white blood cell count before and after treatment in the infection group;comparison of procalcitonin,C-reactive protein and white blood cell count before and after treatment between the mild group and the severe group.Results In the infection group,the procalcitonin was(20.23±5.03)ng/ml,the C-reactive protein was(60.90±21.04)mg/L and the white blood cell count was(20.88±3.71)×10^(9)/L,which were significantly higher than(0.49±0.18)ng/ml,(5.08±0.72)mg/L and(6.04±1.25)×10^(9)/L in the reference group(P<0.05).In the severe group,the procalcitonin was(33.05±8.21)ng/ml,the C-reactive protein(98.76±16.35)mg/L and the white blood cell count was(29.74±3.35)×10^(9)/L,which were significantly higher than(7.41±1.98)ng/ml,(23.04±7.82)mg/L and(12.01±2.57)×10^(9)/L in the mild group(P<0.05).The positive detection rate of procalcitonin test for respiratory infection was 96.00%,which was higher than that of C-reactive protein test(80.00%)and white blood cell count test(74.00%)(P<0.05).The difference between the positive detection rate of respiratory infection by C-reactive protein test and white blood cell count test was not statistically significant(P>0.05).After treatment,the procalcitonin of the infection group was(6.53±2.01)ng/ml,the C-reactive protein was(8.21±1.24)mg/L and the white blood cell count was(8.64±1.33)×10^(9)/L,which were significantly lower than those before treatment(P<0.05).After treatment,the procalcitonin,C-reactive protein and white blood cell count in both the mild group and severe group were lower than those before treatment(P<0.05).Conclusion Testing procalcitonin in patients with respiratory infection can not only confirm the diagnosis of infection,but also understand the degree of infection,which can provide a reference for treatment,and evaluate the prognosis.