血清CK-MB水平与急性心肌梗死患者病情严重程度的关系分析

Correlation analysis between serum CK-MB levels and severity of acute myocardial infarction in patients

目的研究血清肌酸激酶同工酶(CK-MB)水平与急性心肌梗死(AMI)患者病情严重程度的关系。方法择选98例AMI患者,收集其病例信息作回顾性分析,按照病情严重程度不同将其分为较重组、较轻组,分别为35、63例。对比两组临床资料[年龄、性别、吸烟史、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、心率(HR)、心肌肌钙蛋白I(cTnI)、心脏型脂肪酸结合蛋白(H-FABP)、CK-MB],并对其做Logistic回归分析,分析AMI患者病情严重程度的影响因素。结果两组在年龄、性别、吸烟史、LDL-C、HDL-C、HR上差异不明显(P>0.05);在cTnI、H-FABP、CK-MB上,较重组分别为(25.62±5.24)、(122.18±20.65)、(64.08±12.17)ng/ml,均高于较轻组的(16.41±4.28)、(56.57±23.12)、(25.94±18.54)ng/ml,差异明显(P<0.05)。Logistic回归分析发现,cTnI、H-FABP不是AMI疾病严重程度的独立影响因素(OR=1.373、1.652,P>0.05),CK-MB是AMI疾病严重程度的独立影响因素(OR=2.186,P<0.05)。结论血清CK-MB水平与AMI患者病情严重程度密切相关,CK-MB过高是AMI病情严重的独立危险因素。

Objective To study the correlation between serum creatine kinase isoenzyme(CK-MB)levels and severity of acute myocardial infarction(AMI)in patients.Methods A total of 98 AMI patients was collected for retrospective analysis,and they were divided into a heavier group and a lighter group according to the severity of the disease,with 35 and 63 cases,respectively.The clinical data[age,gender,smoking history,low-density lipoprotein(LDL-C),high-density lipoprotein(HDL-C),heart rate(HR),cardiac troponin(cTnI),heart type fatty acid binding protein(H-FABP),CK-MB]were compared between the two groups,and Logistic regression analysis was done to analyze factors influencing the severity of AMI patients.Results There were no significant differences in age,gender,smoking history,LDL-C,HDL-C and HR between the two groups(P>0.05).The cTnI,H-FABP and CK-MB were(25.62±5.24),(122.18±20.65)and(64.08±12.17)ng/ml in the heavier group,which were higher than(16.41±4.28),(56.57±23.12)and(25.94±18.54)ng/ml in the lighter group,and the differences were significant(P<0.05).Logistic regression analysis showed that cTnI and H-FABP were not independent factors influencing the severity of AMI(OR=1.373,1.652;P>0.05),CK-MB was an independent factor affecting the severity of AMI(OR=2.186,P<0.05).Conclusion The serum CK-MB level is closely related to the severity of AMI patients,and excessive CK-MB is an independent risk factor for the severity of AMI.