血府逐瘀汤结合针灸治疗冠心病不稳定型心绞痛患者的临床疗效及安全性分析

Clinical efficacy and safety analysis of Xuefu Zhuyu Decoction combined with acupuncture in treating patients with unstable angina pectoris of coronary heart disease

目的分析对冠心病不稳定型心绞痛患者开展血府逐瘀汤联合针灸治疗的疗效,并分析其对患者心功能指标、心绞痛发作情况、治疗期间不良反应发生率的影响。方法108例冠心病不稳定型心绞痛患者,以1∶1形式将其分成对照组(54例)和研究组(54例)。两组患者均按照冠心病指南予以常规药物治疗,研究组患者再予以血府逐瘀汤联合针灸治疗。比较两组患者治疗后的临床疗效,治疗前后的心功能指标[左室舒张末期容积(LVEDV)、左室收缩末期容积(LVESV)、左室射血分数(LVEF)]及心绞痛发作情况(心绞痛发作持续时间、心绞痛发作频率),不良反应发生情况。结果研究组临床总有效率96.30%比对照组85.19%更高(P<0.05)。治疗后,两组LVEDV、LVESV较治疗前缩小,LVEF较治疗前升高,且研究组LVEDV(159.72±16.58)ml、LVESV(92.51±10.07)ml小于对照组的(174.61±16.76)、(102.61±10.83)ml,LVEF(59.28±6.02)%高于对照组的(56.12±5.74)%(P<0.05)。治疗后,两组心绞痛发作持续时间较治疗前缩短,心绞痛发作频率较治疗前减少,且研究组心绞痛发作持续时间(1.16±0.17)min短于对照组的(3.04±0.54)min、心绞痛发作频率(1.57±0.34)次/周少于对照组的(3.67±1.02)次/周(P<0.05)。两组患者治疗期间不良反应发生率比较无显著性差异(P>0.05)。结论血府逐瘀汤结合针灸治疗能够提升冠心病不稳定型心绞痛患者的临床疗效,改善心功能,减少心绞痛发作,且未增加患者不良反应,该方案是治疗冠心病不稳定型心绞痛患者的更优方案。

Objective To analyze the efficacy of Xuefu Zhuyu Decoction combined with acupuncture on patients with unstable angina pectoris of coronary heart disease,and its influence on patients'cardiac function indicators,angina pectoris attack and the incidence of adverse reactions during treatment.Methods 108 patients with unstable angina pectoris of coronary heart disease were divided into a control group(54 cases)and a study group(54 cases)at a 1‥1 ratio.Both groups were treated with conventional drugs according to coronary heart disease guidelines,and the study group was treated with Xuefu Zhuyu Decoction combined with acupuncture.Both groups were compared in terms of clinical efficacy,cardiac function indicators[left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),left ventricular ejection fraction(LVEF)],angina pectoris attack(duration of angina attack,frequency of angina attack)before and after treatment and adverse reactions.Results The total clinical effective rate of the study group was 96.30%,which was higher than 85.19%of the control group(P<0.05).After treatment,LVEDV and LVESV decreased and LVEF increased in both groups compared with those before treatment;the study group had LVEDV of(159.72±16.58)ml and LVESV of(92.51±10.07)ml,which were smaller than(174.61±16.76)and(102.61±10.83)ml in the control group;LVEF of(59.28±6.02)%in the study group was higher than(56.12±5.74)%in the control group(P<0.05).After treatment,the duration of angina attacks was shorter and the frequency of angina attacks was less in both groups compared with those before treatment;the duration of angina attack of(1.16±0.17)min in the study group was shorter than(3.04±0.54)min in the control group,and the frequency of angina attack of(1.57±0.34)times/week was less than(3.67±1.02)times/week in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion The combination of Xuefu Zhuyu Decoction with acupuncture can enhance the clinical efficacy of patients with unstable angina of coronary heart disease,improve cardiac function,and reduce angina pectoris attack without increasing the adverse reactions of the patients.So this regimen is a more optimal regimen for the treatment of patients with unstable angina of coronary heart disease.