血清CRP、脂肪酶联合淀粉酶检测在急性胰腺炎早期诊断中的应用

Application of serum CRP,lipase combined with amylase in early diagnosis of acute pancreatitis

目的目的分析血清C反应蛋白(C-reactive protein,CRP)、脂肪酶(lipase,LIP)联合淀粉酶(amylase,AMY)检测在急性胰腺炎(Acute pancreatitis,AP)早期诊断中的应用价值。方法方法选取2022年1月~2023年6月在本院治疗的83例AP患者为研究对象(观察组),另选取同期在本院行体检的35例健康者为对照组。对比两组血清CRP、LIP、AMY水平;分析血清CRP、LIP、AMY单独检测和联合检测诊断效能及阳性预测值、阴性预测值。结果结果观察组血清CRP、LIP、AMY水平明显比对照组高(P<0.05);血清CRP、LIP、AMY联合检测灵敏度、特异度、准确度分别为90.00%、78.79%、85.54%,均高于血清CRP、LIP、AMY单独检测;血清CRP、LIP、AMY联合检测阳性、阴性预测值分别为86.54%、83.87%,均高于血清CRP、LIP、AMY单独检测(P<0.05)。结论结论血清CRP、LIP、AMY联合检测在AP患者诊断中具有较高的诊断价值,且为AP患者病情发展提供重要方向,能成为临床早期AP患者诊断的可靠依据。

Objective To analyze the function of serum C-reactiveprotein(CRP),lipase(LIP)combined with amylase(AMY)in the early diagnosis of Acutepancreatitis(AP).Methods 83 AP patients treated in our hospital from January 2022 to June 2023 were selected as the study subjects(observation group),another 35 healthy subjects who underwent physical examination in our hospital during the same period were selected as the control group.The serum levels of CRP,LIP and AMY were compared between the two groups;the diagnostic efficacy and positive and negative predictive values of serum CRP,LIP and AMY alone dectction and com-bined dectction were analyzed.Results The serum levels of CRP,LIP and AMY in observation group were significantly higher than those in control group(P<0.05);the sensitivity,specificity and accuracy of serum CRP,LIP and AMY combined detection were 90.00%,78.79%and 85.54%,respectively,which were higher than that of serum CRP,LIP and AMY alone detetion;the positive and negative predictive values of serum CRP,LIP and AMY combined detection were 86.54%and 83.87%,respectively,which were higher than those of serum CRP,LIP and AMY alone detection(P<0.05).Conclusion The combined detection of serum CRP,LIP and AMY has a high diagnostic value in the diagnosis of AP patients,and can provide an important direction for the development of AP patients,and can be a reliable basis for the early diagnosis of AP patients.