摘要
Autophagy is a highly conserved bulk degradation mechanism that degrades damaged organelles,aged proteins and intracellular contents to maintain the homeostasis of the intracellular microenvironment.Activation of autophagy can be observed during myocardial injury,during which inflammatory responses are strongly triggered.Autophagy can inhibit the inflammatory response and regulate the inflammatory microenvironment by removing invading pathogens and damaged mitochondria.In addition,autophagy may enhance the clearance of apoptotic and necrotic cells to promote the repair of damaged tissue.In this paper,we briefly review the role of autophagy in different cell types in the inflammatory microenvironment of myocardial injury and discuss the molecular mechanism of autophagy in regulating the inflammatory response in a series of myocardial injury conditions,including myocardial ischemia,ischemia/reperfusion injury and sepsis cardiomyopathy.
基金
supported by the National Natural Science Foundation of China(82104495 and 82174161)
Shenzhen Fundamental Research Program(No.SGDX20210823103804030)
Science and Technology Development Fund,Macao SAR(No.0025/2022/A1)
University of Macao grants(No.MYRG2019-00129-ICMS)
Macao Youth Scholars Program(AM2021023)
Guangdong Basic and Applied Basic Research Foundation(2022A1515010395 and 2021A1515012573)
Science and Technology Foundation of Guangzhou City(202102010257)
State Key Laboratory of Dampness Syndrome of Chinese Medicine Research Foundation(SZ2021ZZ21 and SZ2022QN02)
Scientific Research Projects of Guangdong Bureau of Traditional Chinese Medicine(Nos.20212088)
TCM Research Fund of Guangdong Provincial Hospital of Chinese Medicine(YN2020MS13)
The 2020 Guangdong Provincial Science and Technology Innovation Strategy Special Fund(Guangdong-Hong Kong-Macao Joint Lab,No.2020B1212030006 and MY2022KF05).
