胃蛋白酶原和胃泌素17联合检测在胃癌诊断中的价值

Value of Pepsinogen and Gastrin 17 for the Diagnosis of Gastric Cancer

目的:探讨人血清胃蛋白酶原(PG)和胃泌素17(G-17)联合检测对胃癌早期诊断的价值。方法:以中山大学孙逸仙纪念医院2020年11月至2021年4月诊治的胃癌患者血清标本40例为胃癌组,选择同期体检健康人群的血清标本30例为健康对照组。采用双位点夹心化学发光免疫分析法检测两组血清PGI、PGⅡ水平;采用荧光免疫层析法检测两组血清G-17水平,比较两组间各指标的差异;采用单因素logistics回归模型计算预测因子,使用受试者工作特征曲线(ROC)和曲线下面积(AUC)评价各指标单独检测和联合检测的诊断效能。结果:胃癌组的血清PGI、PGⅡ和G-17水平均显著高于健康对照组(P<0.05)。PGI、PGⅡ和G-17单独检测时,AUC值分别为0.749、0.734、0.785,三者联合检测时AUC为0.822,显著高于单独检测或两项组合检测的AUC值,且差异有统计学意义(P<0.05)。结论:PGI、PGⅡ和G-17联合检测在胃癌早期诊断中有较高的诊断效能,可作为一种有效的非侵入性筛查方法。

Objective:To investigate the value of Pepsinogen(PG)and Gastrin 17(G-17)for the diagnosis of gas-tric cancer.Methods:Serum samples from 40 patients with gastric cancer and 30 healthy as gastric cancer group and control group were analyzed from Nov 2020 to Apr 2021 in the hospital.PGI,PGⅡlevels were measured using chemilu-minescence immunoassay,and G-17 levels with fluorescence immunochromatography.Differences in marker expression were assessed,and logistics regression model,receiver operating characteristic curve(ROC)and under area curve(AUC)was used for diagnostic evaluation between the two groups.Results:Serum levels of PGI,PGⅡand G-17 were significantly higher in the gastric cancer group than those in the control group(all P<0.05).The AUCs for PGI,PGⅡand G-17 were 0.749,0.734 and 0.785,respectively.Combined detection yielded an AUC of 0.822,was significantly bet-ter than individual or paired tests(P<0.05).Conclusion:Combined detection of PG I,PGⅡand G-17 offers high di-agnostic efficiency for early gastric cancer detection,serving as an effective non-invasive screening method.