摘要
Hematopoietic stem cells(HSCs)are critical for the treatment of a variety of hematological diseases.However,the low number of HSCs lead to the clinical application difficult.To gain more functional human HSCs ex vivo,Sakurai et al.established a recombinant-cytokine-free and albumin-free culture system,i.e.PCL-PVAc-PEG-based culture,in combination with 740Y-P,butyzamide and UM171,to improve the long-term expansion of human cord blood HSCs.
基金
supported by grants from the National Key Research and Development Program of China(2018YFA0800200 and 2018YFA0801000)
the National Natural Science Foundation of China(31830061,32030032,32200677)
the Strategic Priority Research Program of the Chinese Academy of Sciences,China(XDA16010207).
