摘要
Three new amide derivatives(alteralkaloids A-C,1-3)and three known alkaloids(4-6)were afforded after phytochemical investigation of fungus Alternaria brassicicola.The structures of these compounds were confirmed by NMR spectroscopic and HRESIMS data.Furthermore,the absolute configuration of 1 was determined using the single-crystal X-ray diffraction analysis.Compounds 1-3 belong to a class of amide derivatives that have not been found in nature before,sharing the same characteristic signals of the butyl moiety and amide group.These isolated compounds mentioned above were tested for the cytotoxic activity.
基金
the National Program for Support of Top-notch Young Professionals(No.0106514050)
the National NSFC(Nos.82273811 and 82104043)
the National Key R&D Program of China(No.2021YFA0910500)
the National NSF for Distinguished Young Scholars(No.81725021)
the Innovative Research Groups of the National NSFC(No.81721005)
the Academic Frontier Youth Team of HUST(No.2017QYTD19).
