血清ProGRP、CA242、PCT水平与慢性萎缩性胃炎肠化生患者Hp感染、预后的关系

Relationship of serum ProGRP,CA242 and PCT levels with Hp infection and prognosis in patients with chronic atrophic gastritis

目的分析慢性萎缩性胃炎肠化生患者血清ProGRP、CA242、PCT水平及与Hp感染及预后的相关性。方法选取蒙城县第一人民医院2020年6月至2022年6月收治的慢性萎缩性胃炎肠化生患者86例为研究对象,根据是否感染Hp划分为A组(未感染Hp,26例)、B组(感染Hp,60例)。根据Hp根治情况,将B组患者分为预后良好组(根治Hp,45例)和预后不良组(未根治Hp,15例)。比较A组与B组、预后不良组与预后良好组的ProGRP、CA242、PCT水平,分析ProGRP、CA242、PCT水平与Hp感染及预后的相关性,分析ProGRP、CA242、PCT单独及联合检测慢性萎缩性胃炎肠化生Hp感染的价值。结果B组ProGRP、CA242、PCT水平均高于A组,差异有统计学意义(t=7.927、8.288、5.419,P<0.05)。预后不良组ProGRP、CA242、PCT水平均高于预后良好组,差异有统计学意义(t=11.092、6.897、3.788,P<0.05)。ProGRP、CA242、PCT水平与Hp感染及预后不良均呈正相关关系(r=0.723、0.711、0.688、0.725、0.722、0.701,P<0.05)。ROC曲线结果显示,联合诊断的AUC为0.912,分别大于ProGRP、CA242、PCT单独诊断的0.899、0.871、0.886(P<0.05)。结论ProGRP、CA242、PCT水平与慢性萎缩性胃炎肠化生患者Hp感染及Hp感染患者的预后密切相关,三者联合检测对慢性萎缩性胃炎肠化生患者Hp感染具有较高的诊断价值。

Objective To analyze the correlation between serum levels of ProGRP,CA242,PCT,Hp infection,and prognosis in patients with intestinal metaplasia of chronic atrophic gastritis.Methods 86 patients with chronic atrophic gastritis and intestinal metaplasia admitted to the First People's Hospital of Mengcheng County from June 2020 to June 2022 were selected as the research subjects.According to whether they were infected with Hp,they were divided into group A(26 cases without Hp infection)and group B(60 cases with Hp infection).Based on the curative effect of Hp,group B patients were divided into a group with good prognosis(45 cases with curative Hp)and a group with poor prognosis(15 cases without curative Hp).The study aimed to compare the ProGRP,CA242,and PCT levels between group A and group B,as well as between the poor prognosis group and the good prognosis group,also to analyze the correlation between ProGRP,CA242,and PCT levels and Hp infection and prognosis.This study also aimed to evaluate the value of ProGRP,CA242,and PCT alone and in combination for detecting Hp infection in intestinal metaplasia of chronic atrophic gastritis.Results The levels of ProGRP,CA242 and PCT in group B were higher than those in group A,and the differences were statistically significant(t=7.927,8.288,5.419,P<0.05).ProGRP,CA242 and PCT levels in the poor prognosis group were higher than those in the good prognosis group(t=11.092,6.897,3.788,P<0.05).ProGRP,CA242,and PCT levels were positively correlated with HP infection and poor prognosis(r=0.723,0.711,0.688,0.725,0.722,0.701,P<0.05).The ROC curve showed that the AUC of combined diagnosis was 0.912,which was higher than 0.899,0.871 and 0.886 of ProGRP,CA242 and PCT alone(P<0.05).Conclusion The levels of ProGRP,CA242,and PCT are closely related to Hp infection and prognosis in patients with chronic atrophic gastritis and intestinal metaplasia.The combined detection of the three markers has high diagnostic value for Hp infection in patients with chronic atrophic gastritis and intestinal metaplasia.