脓毒症患者血清PCT、IL-6及铁蛋白水平与并发多器官功能障碍综合征的相关性

Correlation of serum levels of PCT,IL-6 and ferritin with concurrent multiple organ dysfunction syndrome in sepsis patients

目的探究脓毒症患者血清降钙素原(PCT)、白细胞介素-6(IL-6)及铁蛋白水平与并发多器官功能障碍综合征(MODS)的相关性。方法观察性研究。抽取2022年1月至2023年12月濮阳市人民医院收治的66例脓毒症患者,根据是否发生MODS将其分为MODS组(34例)和非MODS组(32例)。检测并比较两组PCT、IL-6和铁蛋白水平。比较MODS组治疗前后血清PCT、IL-6及铁蛋白水平。比较两组脓毒症危重评分[急性生理与慢性健康状况评分系统II(APACHEⅡ)评分、脓毒症相关性器官功能衰竭评价(SOFA)评分、Marshall评分]。采用Pearson相关性检验评估PCT、IL-6及铁蛋白水平与脓毒症患者发生MODS的相关性。结果MODS组血清PCT、IL-6及铁蛋白水平均高于非MODS组(P<0.05)。MODS组中,治疗后血清PCT、IL-6及铁蛋白水平均低于治疗前(P均<0.05)。MODS组APACHEⅡ、SOFA、Marshall评分均高于非MODS组(P均<0.05)。Logistics多因素回归分析结果显示,血清PCT、IL-6和铁蛋白水平是脓毒症患者发生MODS的危险因素,PCT、IL-6和铁蛋白水平越高MODS的发生风险越高(OR>1,P<0.05)。结论在并发MODS的脓毒症患者中,血清PCT、IL-6和铁蛋白水平明显上升,其水平越高患者发生MODS的风险也越大。

ObjectiveTo investigate the correlation of serum levels of procalcitonin(PCT),interleukin-6(IL-6)and ferritin with concurrent multiple organ dysfunction syndrome(MODS)in patients with sepsis.MethodsA observational study was conducted on 66 patients who underwent treatment for sepsis in Puyang People’s Hospital from January 2022 to December 2023,and they were divided into two the MODS group(34 cases)and the non MODS group(32 cases)according to whether they had MODS.The levels of PCT,IL-6 and ferritin in the two groups were detected and compared.In the MODS groups,the preoperative and postoperative levels of PCT,IL-6 and ferritin were compared.The critical illness scores including acute physiology and chronic health evaluation II(APACHE II)score,sepsis-related organ failure assessment(SOFA)score and Marshall score,were compared between the two groups.Pearson correlation analysis was used to analyze the correlation between levels of PCT,IL-6 and ferritin with occurrence of MODS in sepsis patients.ResultsThe serum levels of PCT,IL-6,and ferritin in the MODS group were higher than those in the non MODS group(P<0.05).The serum levels of PCT,IL-6,and ferritin in the MODS group after treatment were lower than those before treatment(all P<0.05).The scores of APACHE II,SOFA and Marshall of the MODS group were all higher than those of the non MODS group(all P<0.05).According to logistic multi-variate regression analysis,serum levels of PCT,IL-6 and ferritin were risk factors for occurrence of MODS in sepsis patients,and the occurrence risk of MODS increases with the increase in levels of PCT,IL-6 and ferritin(OR>1,P<0.05).ConclusionsIn sepsis patients with concurrent MODS,the serum levels of PCT,IL-6,and ferritin are significantly elevated.The occurrence risk of MODS increases with the increase in levels of PCT,IL-6 and ferritin.