莫沙必利与多潘立酮治疗原发性胆汁反流性胃炎的效果比较

Comparison of therapeutic effects of mosapride and domperidone on primary bile reflux gastritis

目的比较莫沙必利与多潘立酮治疗原发性胆汁反流性胃炎(BRG)的效果。方法队列研究。抽取2021年1月至2023年6月聊城市第二人民医院收治的原发性BRG患者62例,采用随机数字表法分为对照组和干预组,每组31例。所有患者均接受铝碳酸镁及奥美拉唑辅助治疗,在此基础上,对照组予以多潘立酮治疗,干预组予以莫沙必利治疗,两组均治疗4周。观察两组临床疗效,比较两组治疗前及治疗后24 h胆汁变化及血清胃泌素(GAS)水平变化。结果干预组疗效分级优于对照组(P<0.05),但总有效率与对照组比较差异未见统计学意义(P>0.05)。治疗后,两组24 h反流次数、最长反流持续时间、反流总时间比率及反流>5 min次数均少于治疗前,且干预组少于对照组(P<0.05);治疗后,两组血清GAS水平均高于治疗前,且干预组高于对照组(P<0.05)。结论与多潘立酮比较,原发性BRG患者采用莫沙必利治疗疗效更明显,更有利于减轻胆汁反流,改善血清GAS水平。

ObjectiveTo compare the effect of mosapride and domperidone in the treatment of primary bile reflux gastritis.MethodsA total of 62 patients with primary bile reflux gastritis admitted to the Second People’s Hospital of Liaocheng from January 2021 to June 2023 were selected for the cohort study.And they were divided into the control group and the intervention group by random number table method,with 31 cases in each group.All patients received adjuvant treatment with magnesium aluminate carbonate and omeprazole;in addition,the control group was treated with domperidone,and the intervention group was treated with mosapride.Both groups were treated for 4 weeks.The clinical efficacy of the two groups was observed,and the preoperative and postoperative changes in 24-hour levels of bile and serum gastrin(GAS)were compared in both groups.ResultsThe efficacy grade of the intervention group was better than that of the control group(P<0.05),but there was no significant difference in total effective rate between the two groups(P>0.05).After treatment,the number of regurgitation within 24 hours,the longest duration of regurgitation,the ratio of total regurgitation time and the number of regurgitation>5 minutes in both groups were lower than those before treatment,and the above indexes in the intervention group were lower than those in the control group(P<0.05).The postoperative level of serum GAS of the two groups were higher than preoperative levels,and the intervention group had higher level of GAS compared with the control group(P<0.05).ConclusionsCompared with domperidone,mosapride has a more significant therapeutic effect on patients with primary bile reflux gastritis,which is more conducive to reducing bile reflux and improving serum GAS level.