妊娠期糖尿病诊断中糖化血红蛋白与糖耐量联合检测的应用效果

Efficacy of Glycosylated Hemoglobin A1c and Glucose Tolerance in the Diagnosis of Gestational Diabetes Mellitus

目的探究糖化血红蛋白(glycosylated hemoglobin A1c,HbA1c)联合糖耐量检测在妊娠期糖尿病(gesta-tional diabetes mellitus,GDM)诊断中的应用效果。方法选择2022年1月—2024年3月到淄博市博山区计划生育服务中心区妇幼保健院就诊的163例GDM患者(观察组)及163例健康体检孕妇(对照组)为研究对象,两组均行HbA1c、糖耐量检测,比较两组空腹血糖、HbA1c、服糖后1 h及2 h血糖值,以受试者操作特征(re-ceiver operating characteristic,ROC)曲线分析单一指标检测及联合检测的诊断效能。结果ROC曲线分析结果显示,GDM诊断中HbA1c与糖耐量联合检测的诊断效能最高(曲线下面积为0.999,95%CI:0.986~1.000,灵敏度为98.77%,特异度为98.16%)。结论GDM诊断中HbA1c联合糖耐量检测结果的诊断价值较高。

Objective To explore the application effect of glycosylated hemoglobin A1c(HbA1c)combined with glu-cose tolerance test in the diagnosis of gestational diabetes mellitus(GDM).Methods A total of 163 GDM patients(ob-servation group)and 163 healthy pregnant women(control group)who visited the Maternal and Child Health Hospital of Boshan Family Planning Service Center of Zibo City from January 2022 to March 2024 were selected as the study objects.HbA1c and glucose tolerance tests were performed in both groups,and fasting plasma glucose,HbA1c,blood glucose at 1 h and 2 h after taking glucose were compared between the two groups.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic efficiency of single index detection and combined detection.Results ROC curve analysis results showed that the combined detection of HbA1c and glucose tolerance had the highest diag-nostic efficiency in GDM diagnosis(area under the curve:0.999,95%CI:0.986-1.000,sensitivity was 98.77%,speci-ficity was 98.16%).Conclusion The diagnostic value of HbA1c combined with glucose tolerance test results in GDM diagnosis is high.