释氧生物材料用于组织工程的研究进展

Research progress of oxygen-releasing biomaterials for tissue engineering

一定程度的局部缺氧会引起不同水平的组织细胞损伤,释氧生物材料能持续给移植细胞供氧。近年来,许多研究致力于开发更有应用价值的释氧生物材料和体系,来增加体内的氧气输送以保证植入组织的有效氧供。根据提供氧气的形式释氧生物材料可以分为携氧材料和产氧材料。前者基于特定条件下结合氧分子后提供治疗性氧合,后者则是借助氧源材料组合入聚合物内,通过在体内的水解达到氧气释放的效果。文章归纳和总结携氧材料发展现状与产氧材料的氧源供应、装载材料和控制释放等多方面的最新研究,论述释氧生物材料进行氧气递送的实践应用和控制缓释的一系列方案。

Some degree of localized hypoxia can cause varying degrees of cellular damage in tissues.Oxygen-releasing biomaterials can sustainably provide oxygen to transplanted cells.In recent years,extensive research efforts have been dedicated to developing more pratical oxygen-releasing biomaterials and systems to enhance oxygen delivery in vivo and ensure effective oxygen supply to implanted tissues.Based on the form of oxygen provision,these materials can be calssified into oxygen-carrying materials and oxygen-producing materials.The former deliver therapeutic oxygenation by binding oxygen molecules under specific conditions,while the latter incorporate oxygen source materials into polymers,achieving oxygen release through in vivo hydrolysis.This paper summarizes the current development of oxygen-carrying materials and oxygen-producing materials,including oxygen source supply,loading materials,and controlled release.It discusses practical application of oxygen-releasing biomaterials for oxygen delivery and various strategies for controlled release.