核转录因子红细胞2相关因子2在糖尿病心肌缺血再灌注损伤中的研究进展

Research progress of NRF2 in diabetic myocardial ischemia-reperfusion injury

目的:糖尿病作为最常见的代谢性疾病,与心血管疾病密切相关,是急性心肌梗死发生的独立危险因素。核转录因子红细胞2相关因子2(nuclear factor erythroid-2-related factor 2,NRF2)是细胞抗氧化反应的关键,它可通过与其他蛋白质相互作用并与抗氧化反应元件结合来增加下游抗氧化基因的转录,维持氧化还原反应的动态平衡。研究表明,NRF2参与调控糖尿病心肌缺血再灌注损伤的发生发展,但其机制尚不完全清楚,文章主要综述与糖尿病心肌缺血再灌注损伤相关的NRF2信号通路及NRF2靶向治疗的研究进展,为糖尿病心肌缺血再灌注损伤的临床治疗提供新的思路。

Objective:As the most common metabolic disease,diabetes is closely related to cardiovascular disease and is an independent risk factor for the occurrence of acute myocardial infarction.Nuclear factor erythroid-2-related factor 2(NRF2)is a key regulator of the cellular antioxidant response,which increases the transcription of downstream antioxidant genes by interacting with other proteins and binding to antioxidant response elements,thereby maintaining the dynamic balance of redox states.Some studies have shown that NRF2 is involved in the regulation of the occurrence and development of diabetic myocardial ischemia-reperfusion injury,but its mechanism is not yet fully understood.This paper mainly reviews the research progress of NRF2 signaling pathway related to diabetic myocardial ischemia-reperfusion injury and NRF2 targeted therapies,providing new insights for the clinical treatment of diabetic myocardial ischemia-reperfusion injury.