脂联素与衰弱相关性的研究进展

Research progress on the correlation between adiponectin and frailty

衰弱作为一种与增龄相关的老年综合征,已成为威胁老年人健康的重要社会问题,对衰弱的早期识别和干预有助于减少其导致的临床负性事件的发生,对提高老年人患者生活质量、预防过早死亡和延长期望寿命具有重要意义。脂联素作为一种具有多种生理作用的脂肪细胞因子,有可能成为衰弱的潜在生物标志物。该文对脂联素与老年人衰弱的相关性研究进展进行了综述,旨在为脂联素作为衰弱生物标志物及后续相关治疗药物研发提供参考依据。

As an age-related geriatric syndrome,frailty has become an important social problem that threatens the health of the elderly.Early identification and intervention of frailty can help reduce the occurrence of clinical negative events caused by frailty.It is of great significance to improve the quality of life of elderly patients,prevent premature death and prolong life expectancy.Adiponectin,as an adipocytokine with a variety of physiological effects,may become a potential biomarker for frailty.This article reviews the research on the correlation between adiponectin and frailty in the elderly,aiming to provide a reference for the development of adiponectin as a biomarker of frailty and subsequent related therapeutic drugs.