AECOPD并发肺栓塞患者血清SFRP1、DFR、Irisin水平及其与预后的关系

The relationship between serum SFRP1,DFR,Irisin levels and prognosis in patients with AECOPD complicated with pulmonary embolism

目的探讨急性加重期慢性阻塞性肺疾病(AECOPD)并发肺栓塞患者的血清分泌型卷曲相关蛋白1(SFRP1)、D-二聚体与纤维蛋白原比值(DFR)、鸢尾素(Irisin)水平及其预测预后的临床价值。方法回顾性选取2021年1月至2023年12月武汉市第一医院收治的AECOPD并发肺栓塞患者,根据住院期间生存结局分为生存组50例和死亡组10例。对比两组患者的一般临床资料和血清SFRP1、DFR、Irisin水平,采用logistic回归模型分析AECOPD病程及SFRP1、DFR、Irisin水平与AECOPD合并肺栓塞患者不良预后的相关性,绘制受试者工作特征(ROC)曲线分析SFRP1、DFR、Irisin预测AECOPD合并肺栓塞患者不良预后的价值。结果两组患者的AECOPD病程差异具有统计学意义(P<0.05)。两组患者血清SFRP1、DFR、Irisin水平差异具有统计学意义(均P<0.05)。Logistic回归分析结果显示,SFRP1、DFR、Irisin(OR=1.022、4.991、0.719)是AECOPD并发肺栓塞患者预后结局的影响因素(均P<0.05)。ROC曲线分析结果显示,SFRP1、DFR、Irisin预测AECOPD并发肺栓塞患者不良预后结局的曲线下面积(AUC)分别为0.844、0.920、0.842。结论SFRP1、DFR、Irisin是AECOPD并发肺栓塞患者不良预后的影响因素,且对于预测AECOPD并发肺栓塞患者预后具有较高的价值。

ObjectiveTo investigate the clinical value of serum levels of secreted frizzled related protein 1(SFRP1),D-dimer to fibrinogen ratio(DFR),Irisin in predicting prognosis in patients with acute exacerbation of Chronic Obstructive Pulmonary Disease(AECOPD)complicated with pulmonary embolism.MethodsRetrospectively AECOPD patients with concurrent pulmonary embolism admitted to the Wuhan No.1 Hospital from January 2021 to December 2023were selected,and divided into a survival group of 50 cases and a death group of 10 cases based on their survival outcomes during hospitalization.Comparing the general clinical data and serum levels of SFRP1,DFR,and Irisin between two groups of patients,a logistic regression model was used to analyze the correlation between the course of AECOPD,SFRP1,DFR,and Irisin levels and adverse prognosis in AECOPD patients with pulmonary embolism.Receiver operating characteristic(ROC)curves were plotted to analyze the value of SFRP1,DFR,and Irisin in predicting adverse prognosis in AECOPD patients with pulmonary embolism.ResultsThere was a statistically significant difference in the duration of AECOPD between the two groups of patients(P<0.05).The differences in serum SFRP1,DFR,and Irisin levels between the two groups of patients were statistically significant(all P<0.05).The results of logistic regression analysis showed that SFRP1,DFR,and Irisin(OR=1.022,4.991,0.719)were influencing factors on the prognosis of AECOPD patients with pulmonary embolism(all P<0.05).The ROC curve showed that the area under the curve(AUC)of SFRP1,DFR,and Irisin for predicting adverse prognostic outcomes in AECOPD patients with pulmonary embolism was 0.844,0.920,and 0.842,respectively.ConclusionsSFRP1,DFR,and Irisin are influencing factors for poor prognosis in AECOPD patients with pulmonary embolism,and have high value in predicting the prognosis of AECOPD patients with pulmonary embolism.