抗结核药物诱导银屑病消退及斑秃发生1例

Anti-Tuberculosis Drug Induced Regression of Psoriasis and Occurrence of Alopecia Areata:A Case Report

患者男,64岁,弥漫性斑片状脱发1个月。患者有中重度斑块型银屑病病史17年,在使用利福平和异烟肼进行预防性抗结核治疗中,银屑病皮损出现显著缓解,但发生了弥漫性斑片状脱发。在停用抗结核药物和给予肌注及外用糖皮质激素治疗后,斑秃逐渐缓解,但银屑病皮损再次复发,这表明抗结核药物可能通过多个关键因子发挥抗炎和免疫调节作用。

A 64-year-old man presented with diffuse patchy alopecia for one month.He had a 17-year history of moderate to severe plaque psoriasis.Significant resolution of psoriasis lesions occurred during preventive anti-tuberculosis therapy using isoniazid and rifampicin.However,diffuse patchy alopecia areata developed.After withdrawal of anti-tuberculosis drugs and administration of glucocorticoids,alopecia areata was in remission gradually.However,psoriatic lesions returned.Anti-tuberculosis drugs may exert anti-inflammatory and immunomodulatory effects through multiple key factors.