急性缺血性卒中患者发生癫痫的影响因素

Influencing factors of epilepsy in patients with acute ischemic stroke

目的:分析急性缺血性卒中(AIS)患者发生癫痫的影响因素。方法:选取2020年5月至2023年5月该院收治的105例AIS患者进行横断面研究,收集患者的临床资料,统计癫痫发生情况,并依据是否发生癫痫将其分为发生组与未发生组,采用Logistic回归分析AIS患者发生癫痫的影响因素。结果:105例AIS患者中,发生癫痫31例,发生率为29.52%;两组性别、年龄、吸烟、高血压、糖尿病、高脂血症、房颤、癫痫家族史、治疗药物比较,差异均无统计学意义(P>0.05);发生组TOAST分型为心源性栓塞型、病灶部位为皮质、受累动脉系统为颈动脉循环、卒中后病灶区域渗血、美国国立卫生研究院卒中量表(NIHSS)评分>4分占比均高于未发生组,差异有统计学意义(P<0.05);Logistic回归分析结果显示,TOAST分型为心源性栓塞型、病灶部位为皮质、卒中后病灶区域渗血、NIHSS评分>4分均为AIS患者发生癫痫的危险因素(OR>1,P<0.05)。结论:TOAST分型为心源性栓塞型、病灶部位为皮质、卒中后病灶区域渗血、NIHSS评分>4分均为AIS患者发生癫痫的危险因素。

Objective:To analyze influencing factors of epilepsy in patients with acute ischemic stroke(AIS).Methods:A cross-sectional study was conducted on 105 AIS patients admitted to the hospital from May 2020 to May 2023.The clinical data of these patients were collected.The epilepsy conditions were statistically analyzed.According to the occurrence of epilepsy,they were divided into occurrence group and non-occurrence group.Logistic regression was used to analyze the influencing factors of epilepsy in these AIS patients.Results:Among the 105 patients with AIS,31 had epilepsy with an incidence of 29.52%.There were no significant differences in gender,age,smoking,hypertension,diabetes,hyperlipidemia,atrial fibrillation,family history of epilepsy and therapeutic drugs between the two groups(P>0.05).The proportions of the patients with TOAST classification as cardiogenic embolism type,lesion site as cortex,affected arterial system as carotid circulation,oozing blood in the lesion area after stroke,and National Institutes of Health stroke scale(NIHSS)score>4 points in the occurrence group were higher than those in the non-occurrence group,and the differences were statistically significant(P<0.05).Logistic regression analysis showed that TOAST classification as cardiogenic embolism type,lesion site as cortex,oozing blood in the lesion area after stroke and NIHSS score>4 were risk factors for epilepsy in the AIS patients(OR>1,P<0.05).Conclusions:TOAST classification as cardiogenic embolism type,lesion site as cortex,oozing blood in the lesion area after stroke and NIHSS score>4 are the risk factors for epilepsy in the AIS patients。