地衣芽孢杆菌活菌胶囊联合四联疗法治疗老年幽门螺杆菌阳性功能性消化不良患者的效果

Effects of Bacillus licheniformis capsule,live combined with quadruple therapy in treatment of elderly patients with Helicobacter pylori positive functional dyspepsia

目的:观察地衣芽孢杆菌活菌胶囊联合四联疗法治疗老年幽门螺杆菌(Hp)阳性功能性消化不良(FD)患者的效果。方法:选取2020年8月至2023年8月该院收治的280例老年Hp阳性FD患者进行前瞻性研究,按照随机数字表法分为观察组与对照组各140例。对照组采用四联疗法治疗,观察组在对照组基础上联合地衣芽孢杆菌活菌胶囊治疗,比较两组Hp根除率、临床症状(腹胀、上腹痛、食欲不振)缓解时间、肠道菌群数量和不良反应发生率。结果:观察组Hp根除率为95.00%,明显高于对照组的87.86%,差异有统计学意义(P<0.05);观察组腹胀、上腹痛、食欲不振等临床症状缓解时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组双歧杆菌、乳酸杆菌数量高于治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:地衣芽孢杆菌活菌胶囊联合四联疗法用于老年Hp阳性FD患者可提高Hp根除率,缩短临床症状缓解时间,以及改善肠道菌群数量,效果优于单纯四联疗法治疗。

Objective:To observe effects of Bacillus licheniformis capsule,live combined with quadruple therapy in treatment of elderly patients with Helicobacter pylori(Hp)positive functional dyspepsia(FD).Methods:A prospective study was conducted on 280 elderly patients with Hp-positive FD admitted to this hospital from August 2020 to August 2023.According to the random number table method,they were divided into observation group and control group,140 cases in each group.The control group was treated with quadruple therapy,while the observation group was treated with Bacillus licheniformis capsule,live on the basis of that of the control group.The Hp eradication rate,the remission time of clinical symptoms(abdominal distension,upper abdominal pain,loss of appetite),the level of intestinal flora,and the incidence of adverse reactions were compared between the two groups.Results:The Hp eradication rate in the observation group was 95.00%,which was significantly higher than 87.86%in the control group,and the difference was statistically significant(P<0.05).The remission time of clinical symptoms such as abdominal distension,upper abdominal pain and loss of appetite in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of Bifidobacterium and Lactobacillus in two groups were higher than before the treatment,and those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Bacillus licheniformis capsule,live combined with quadruple therapy can improve the Hp eradication rate,shorten the remission time of clinical symptoms and impro ve the level of intestinal flora in the elderly patients with Hp positive functional dyspepsia.Moreover,it is superior to single quadruple therapy.