右佐匹克隆联合草酸艾司西酞普兰治疗卒中后焦虑抑郁伴失眠患者的效果

Effects of Eszopiclone combined with Escitalopram oxalate in treatment of post-stroke anxiety and depression patients with insomnia

目的:观察右佐匹克隆联合草酸艾司西酞普兰治疗卒中后焦虑抑郁伴失眠患者的效果。方法:选取2022年1月至2023年7月该院收治的120例卒中后焦虑抑郁伴失眠患者进行前瞻性研究,按照随机数字表法分为研究组与对照组各60例。对照组采用草酸艾司西酞普兰治疗,研究组在对照组基础上联合右佐匹克隆治疗,比较两组治疗总有效率,匹兹堡睡眠质量评定量表(PSQI)、广泛性焦虑量表(GAD-7)、健康问卷抑郁自评量表(PHQ-9)、蒙特利尔认知评估量表(MoCA),以及不良反应发生率。结果:研究组治疗总有效率为91.67%,明显高于对照组的73.33%,差异有统计学意义(P<0.05);治疗后,两组MoCA评分高于治疗前,且研究组高于对照组,两组PSQI、GAD-7、PHQ-9评分低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:右佐匹克隆联合草酸艾司西酞普兰治疗卒中后焦虑抑郁伴失眠患者可提高治疗总有效率、MoCA评分,降低PSQI、GAD-7、PHQ-9评分,效果优于单纯草酸艾司西酞普兰治疗。

Objective:To observe effects of Eszopiclone combined with Escitalopram oxalate in treatment of post-stroke anxiety and depression patients with insomnia.Methods:A prospective study was conducted on 120 patients with post-stroke anxiety and depression and insomnia admitted to the hospital from January 2022 to July 2023.According to the random number table method,they were divided into study group and control group,60 cases in each group.The control group was treated with Escitalopram oxalate,while the study group was treated with Eszopiclone on the basis of that of the control group.The total effective rate,the scores of Pittsburgh sleep quality index(PSQI),the generalized anxiety scale(GAD-7),the patient health questionnaire(PHQ-9),and the Montreal cognitive assessment scale(MoCA),and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 91.67%,which was significantly higher than 73.33%of the control group,and the difference was statistically significant(P<0.05).After the treatment,the MoCA scores of the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;the PSQI,GAD-7 and PHQ-9 scores of the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Escitalopram oxalate combined with Escitalopram oxalate in the treatment of post-stroke anxiety and depression with insomnia can improve the total effective rate of treatment and the MoCA score,and reduce the PSQI,GAD-7 and PHQ-9 scores.Moreover,it is superior to simple Escitalopram oxalate treatment.