益母草注射联合氨甲环酸预防高危妊娠剖宫产产妇产后出血的效果

Effects of Leonurus injection combined with Tranexamic acid on prevention of postpartum hemorrhage in high-risk pregnant women undergoing cesarean section

目的:探讨益母草注射联合氨甲环酸预防高危妊娠剖宫产产妇产后出血的效果。方法:选取2021年1月至2022年12月该院收治的110例高危妊娠剖宫产产妇进行前瞻性研究,按照随机数字表法将其分为对照组和研究组各55例。两组均常规使用缩宫素预防产后出血,在此基础上对照组联合氨甲环酸治疗,研究组在对照组基础上联合益母草注射液治疗。比较两组止血效果,治疗前后凝血指标[凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)及纤维蛋白原(FIB)]水平,产后2、24 h出血量,止血时间、宫缩持续时间和恶露持续时间,以及不良反应发生率。结果:研究组止血总有效率为94.55%(52/55),高于对照组的81.82%(45/55),差异有统计学意义(P<0.05);治疗后,研究组血浆FIB水平高于对照组,APTT、TT、PT均短于对照组,产后2、24 h出血量均少于对照组,宫缩持续时间长于对照组,止血时间、恶露持续时间均短于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:益母草注射液联合氨甲环酸能有效预防高危妊娠剖宫产产妇发生产后出血,可促进子宫收缩,改善凝血功能,减少产后出血量,缩短止血时间和恶露持续时间,效果优于单用氨甲环酸。

Objective:To explore effects of Leonurus injection combined with Tranexamic acid on prevention of postpartum hemorrhage in high-risk pregnant women undergoing cesarean section.Methods:A prospective study was conducted on 110 high-risk pregnant women undergoing cesarean section admitted to this hospital from January 2021 to December 2022.They were divided into control group and study group according to the random number table method,55 cases in each group.Both groups were routinely used Oxytocin to prevent postpartum hemorrhage.On this basis,the control group was treated with Tranexamic acid,while the study group was treated with Leonurus injection on the basis of that of the control group.The hemostatic effect,the levels of coagulation indexes[thrombin time(TT),prothrombin time(PT),activated partial thromboplastin time(APTT)and fibrinogen(FIB)]before and after the treatment,the amount of bleeding 2 and 24 h after delivery,the hemostatic time,the duration of uterine contraction and the duration of lochia,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of hemostasis in the study group was 94.55%(52/55),which was higher than 81.82%(45/55)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the plasma FIB level in the study group was higher than that in the control group,and the APTT,TT and PT were shorter than those in the control group;the amount of bleeding 2 and 24 hours after delivery were less than those in the control group,and the duration of uterine contraction was longer than that in the control group;the hemostasis time and the duration of lochia were shorter than those in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Leonurus injection combined with Tranexamic acid can effectively prevent postpartum hemorrhage in the high-risk pregnant women undergoing cesarean section,promote the uterine contraction,improve the coagulation function,reduce the postpartum hemorrhage,and shorten the hemostasis time and the duration of lochia.Moreover,it is superior to simple Tranexamic acid treatment.