盐酸氨溴索+阿奇霉素治疗小儿支原体肺炎合并急性支气管炎的疗效分析

Analysis of the Efficacy of Ambroxol Hydrochloride+Azithromycin in Children with Mycoplasma Pneumonia Complicated with Acute Bronchitis

目的探究盐酸氨溴索+阿奇霉素对小儿支原体肺炎合并急性支气管炎的治疗效果及对降钙素原(procalcitonin,PCT)、γ-干扰素(interferon-γ,IFN-γ)、血清超敏C-反应蛋白(hypersensitive C-reactive protein,hs-CRP)水平的影响。方法随机选取2022年12月—2023年12月庆阳市中医医院收治的120例小儿支原体肺炎合并急性支气管炎患儿为研究对象,根据不同治疗方法分为对照组、观察组,每组60例。对照组采用阿奇霉素治疗,观察组采用盐酸氨溴索+阿奇霉素治疗,比较两组的炎性反应、症状改善时间、住院时间、肺功能、血气指标及生活质量。结果治疗后,观察组的PCT(3.99±1.56)μg/L、IFN-γ(9.56±4.26)ng/L、hs-CRP(12.59±5.01)mg/L,均低于对照组的(7.02±2.01)μg/L、(18.59±5.24)ng/L、(20.02±5.95)mg/L,差异有统计学意义(t=9.224、10.357、7.399,P均<0.05)。观察组的症状改善时间及住院时间短于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组的肺功能指标及血气指标优于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组的生活质量评分高于对照组,差异有统计学意义(P<0.05)。结论在治疗小儿支原体肺炎合并急性支气管炎时,选择盐酸氨溴索与阿奇霉素联用的方案,能够显著调节患儿的炎症状态,缩短症状改善时间及住院时间,改善患儿的肺功能。

Objective To explore the therapeutic effect of ambroxol hydrochloride+azithromycin on mycoplasma pneumonia complicated with acute bronchitis in children and its effect on the levels of procalcitonin(PCT),interferon-γ(IFN-γ)and serum hypersensitive C-reactive protein(hs-CRP).Methods A total of 120 children with mycoplasma pneumonia complicated with acute bronchitis admitted to Qingyang Hospital of Traditional Chinese Medicine from December 2022 to December 2023 were randomly selected as the research objects.According to the different treatment methods,they were divided into control group and observation group,with 60 cases in each group.The control group was treated with azithromycin,and the observation group was treated with ambroxol hydrochloride+azithromycin.The inflammatory response,symptom improvement time and hospitalization time,lung function,blood gas index,quality of life of the two groups were compared.Results After treatment,PCT was(3.99±1.56)μg/L,IFN-γwas(9.56±4.26)ng/L and hs-CRP was(12.59±5.01)mg/L in the observation group,which were lower than(7.02±2.01)μg/L,(18.59±5.24)ng/L and(20.02±5.95)mg/L in the control group,and the differences were statistically significant(t=9.224,10.357,7.399,all P<0.05).The symptom improvement time and hospitalization time of the observation group were shorter than those of the control group,and the differences were statistically significant(both P<0.05).After treatment,the lung function and blood gas indexes of the observation group were better than those of the control group,and the differences were statistically significant(both P<0.05).After treatment,the quality of life score of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion In the treatment of mycoplasma pneumonia complicated with acute bronchitis in children, the combination of ambroxol hydrochloride and azithromycin can significantly regulate the inflammatory state of children, shorten the time of symp tom improvement and hospitalization, and improve the lung function of children.